18115-58-7Relevant academic research and scientific papers
Difluoromethylation of Alkyl Bromides and Iodides with TMSCF2H
Zhao, Haiwei,Lu, Changhui,Herbert, Simon,Zhang, Wei,Shen, Qilong
, p. 2854 - 2865 (2021)
We describe, for the first time, two protocols for direct difluoromethylation of unactivated alkyl bromides and iodides. Reactions of alkyl iodides with TMSCF2H were mediated by a copper catalyst using CsF as the activator, while reactions of less reactive alkyl bromides required a combination of palladium and a stoichiometric amount of CuI as the catalysts. Preliminary mechanistic studies of the synergistic Pd/Cu-catalyzed difluoromethylation of alkyl bromides suggest that it proceeds likely via a Pd(I)/Pd(III) catalytic cycle.
Pd(0)-Catalyzed Asymmetric Carbohalogenation: H-Bonding-Driven C(sp3)-Halogen Reductive Elimination under Mild Conditions
Chen, Xin,Zhao, Jixiao,Dong, Ming,Yang, Ninglei,Wang, Jiaoyang,Zhang, Yueqi,Liu, Kun,Tong, Xiaofeng
supporting information, p. 1924 - 1931 (2021/02/06)
Carbon-halogen reductive elimination is a conceptually novel elementary reaction. Its emergence broadens the horizons of transition-metal catalysis and provides new access to organohalides of versatile synthetic value. However, as the reverse process of f
