181189-00-4

Upstream product

• 181188-99-8 4,6-dichloro-8-nitroquinoline 
• 103976-16-5 diethyl N-(4-chloro-2-nitrophenyl)-aminomethylenmalonate 
• 345222-13-1 ethyl 6-chloro-8-nitro-4-oxo-1,4-dihydroquinoline-3-carboxylate 
• 345619-03-6 6-chloro-8-nitro-4-oxo-1,4-dihydroquinoline-3-carboxylic acid 
• 181188-98-7 6-chloro-8-nitroquinolin-4(1H)-one 

Downstream Products

• 181189-01-5 8-amino-6-chloro-4-(4-diethylamino-1-methylbutyl)aminoquinoline 

Relevant academic research and scientific papers

QUINOLINE COMPOUNDS AS H+-ATPASES

This invention relates to a quinoline compound of the formula: wherein R1 is a pyridyl group or aryl, each of which may be substituted with suitable substituent(s), A -COHN-or -NHCO-, n is an integer of 0 or 1, and is a group of the formula: In which R2, R3, R4, R5, R6 and R7 are as defined, and pharmaceutically acceptable salt thereof, to processes for preparation thereof, to a pharmaceutical composition comprising the same, and to a method for the prevention and/or the treatment of bone diseases caused by abnormal bone metabolism in human being or animals.

Novel bisquinoline antimalarials. Synthesis, antimalarial activity, and inhibition of haem polymerisation

We report the synthesis of two series of novel bisquinoline compounds that inhibit the growth of both chloroquine-sensitive and chloroquine-resistant strains of Plasmodium falciparum. To study the molecular basis of the action of these novel antimalarial