181207-93-2Relevant academic research and scientific papers
Stereoselective synthesis of the 6,7,6- and 6,7,7-ring systems of polycyclic ethers by 6-endo cyclization and ring expansion
Mori, Yuji,Yaegashi, Keisuke,Furukawa, Hiroshi
, p. 12917 - 12932 (1997)
A new strategy for the stereoselective synthesis of the trans-fused seven-membered cyclic ethers corresponding to subunits of brevetoxin B and hemibrevetoxin B has been developed. The strategy involves alkylation of an oxiranyl anion and B-endo cyclization followed by one-carbon homologation of a tetrahydropyran to an oxepane using trimethylsilyldiazomethane.
