181226-58-4

Upstream product

• 2525-16-8 O-methylcaprolactim 
• 3883-94-1 2-amino-4'-methoxyacetophenone hydrochloride 

Downstream Products

• 181226-73-3 1-(4-Bromo-phenyl)-4-(4-methoxy-phenyl)-5,6,7,8-tetrahydro-2a,4a-diaza-cyclopenta[cd]azulene 
• 181226-71-1 4-(4-Methoxy-phenyl)-1-phenyl-5,6,7,8-tetrahydro-2a,4a-diaza-cyclopenta[cd]azulene 

Relevant academic research and scientific papers

2a,4a-Diazacyclopenta[c,d]azulenes

A method of preparing 5-aryl-1,2-pentamethyleneimidazoles from O-methylcaprolactim and α-amino-acetophenone hydrochlorides is described. It is shown that 1,2-tri-, -tetra-, and -pentamethyleneimidazoles and phenacyl bromide give the corresponding quaternary imidazolium salts, cyclization of which in the presence of base gives the previously unknown 5, 6, 7, 8-tetrahydro-2a,4a-diazacyclopenta[c, d]azulenes (IVa-i). 1997 Plenum Publishing Corporation.

The derivatives of the 2a,4a-diazacyclopenta[c,d]azulene

The method of preparation of the 3-aryl-6,7,8,9-tetrahydro-5H- imidazo[1,2-a]azepines 2a-d from O-methylcaprolactim and phenacylamine hydrochlorides has been developed. The bases 2 reacted with phenacylbromides to yield the quaternary salts 4a-c. The cyclisation of 4a-c in basic conditions resulted in a new heterocyclic system - the derivatives of 2a,4a- Diazaclopenta[c,d]azulene - 5a-i.