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181227-47-4

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181227-47-4 Usage

Uses

(S)-2-(Tert-Butoxycarbonylamino)-2-(2,3-dihydro-1H-inden-2-yl)acetic Acid is used as an intermediate in the preparation and biological evaluation of bradykinin B1/B2 and selective B1 receptor antagonist.

Check Digit Verification of cas no

The CAS Registry Mumber 181227-47-4 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 1,8,1,2,2 and 7 respectively; the second part has 2 digits, 4 and 7 respectively.
Calculate Digit Verification of CAS Registry Number 181227-47:
(8*1)+(7*8)+(6*1)+(5*2)+(4*2)+(3*7)+(2*4)+(1*7)=124
124 % 10 = 4
So 181227-47-4 is a valid CAS Registry Number.

181227-47-4 Well-known Company Product Price

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  • Aldrich

  • (669792)  Boc-(2-indanyl)-Gly-OH  ≥98.0% (HPLC)

  • 181227-47-4

  • 669792-500MG

  • 2,295.54CNY

  • Detail

181227-47-4SDS

SAFETY DATA SHEETS

According to Globally Harmonized System of Classification and Labelling of Chemicals (GHS) - Sixth revised edition

Version: 1.0

Creation Date: Aug 14, 2017

Revision Date: Aug 14, 2017

1.Identification

1.1 GHS Product identifier

Product name (2S)-2-(2,3-dihydro-1H-inden-2-yl)-2-[(2-methylpropan-2-yl)oxycarbonylamino]acetic acid

1.2 Other means of identification

Product number -
Other names (S)-2-((tert-Butoxycarbonyl)amino)-2-(2,3-dihydro-1H-inden-2-yl)acetic acid

1.3 Recommended use of the chemical and restrictions on use

Identified uses For industry use only.
Uses advised against no data available

1.4 Supplier's details

1.5 Emergency phone number

Emergency phone number -
Service hours Monday to Friday, 9am-5pm (Standard time zone: UTC/GMT +8 hours).

More Details:181227-47-4 SDS

181227-47-4Relevant articles and documents

2,5-Diketopiperazines as potent, selective, and orally bioavailable oxytocin antagonists. 2. Synthesis, chirality, and pharmacokinetics

Borthwick, Alan D.,Davies, Dave E.,Exall, Anne M.,Livermore, David G.,Sollis, Steve L.,Nerozzi, Fabrizio,Allen, Michael J.,Perren, Marion,Shabbir, Shalia S.,Woollard, Patrick M.,Wyatt, Paul G.

, p. 6956 - 6969 (2007/10/03)

A short stereoselective synthesis of a series of chiral 7-aryl-2,5-diketopiperazines oxytocin antagonists is described. Varying the functionality and substitution pattern of substituents in the 7-aryl ring and varying the chirality of this exocyclic ring have produced potent oxytocin antagonists (pKi > 8.5). SAR and pharmacokinetic profiling of this series of (3R,6R,7R)-2,5-diketopiperazines together with the introduction of an ortho F group in the 7-aryl ring to improve rat pK has culminated in the 2′,4′-difluorophenyldiketopiperazine derivative 37, a highly potent oxytocin antagonist against the human oxytocin receptor (pKi = 8.9) that has > 1000-fold selectivity over all three vasopressin receptors V1a, V2, and V1b. It has good bioavailability (46%) in the rat and moderate bioavailability (13-31%) in the dog and is more active in vivo in the rat than atosiban (rat DR10 = 0.44 mg/kg iv).

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