18123-20-1

Basic information

• Product Name: 4-ACRIDINOL
• Synonyms: NEOOXINE;ACRIDIN-4-OL;4-HYDROXYACRIDINE;4-ACRIDINOL;4-Hydroxyacridine, Neooxine;Einecs 242-013-6
• CAS NO: 18123-20-1
• Molecular Formula: C₁₃H₉NO
• Molecular Weight: 195.22
• EINECS: 242-013-6
• Mol File: 18123-20-1.mol
• Article Data: 5

Chemical Properties

• Melting Point: 114-118 °C
• Boiling Point: 416.6°Cat760mmHg
• Flash Point: 205.7°C
• Appearance: /
• Density: 1.307g/cm³
• Vapor Pressure: 1.57E-07mmHg at 25°C
• Refractive Index: 1.767
• Storage Temp.: Sealed in dry,Room Temperature
• PKA: 7.89±0.30(Predicted)
• CAS DataBase Reference: 4-ACRIDINOL(CAS DataBase Reference)
• NIST Chemistry Reference: 4-ACRIDINOL(18123-20-1)
• EPA Substance Registry System: 4-ACRIDINOL(18123-20-1)

Safety Data

• Hazard Codes: Xi
• Statements: 36/37/38
• Safety Statements: 26-36
• WGK Germany: 3
• Hazardous Substances Data: 18123-20-1(Hazardous Substances Data)

Usage

Purification Methods

Crystallise neo-oxine from EtOH or aqueous EtOH. It complexes with Zn2+ , , Ga2+ , Pb2+ , Cr2+ , Mn2+ , Fe2+ , Co2+ and Ni2+ . The hydrochloride crystallises from EtOH with m 242o. [Beilstein 21 II 78, 21 III/IV 1562, 21/4 V 90.]

InChI:InChI=1/C13H9NO/c15-12-7-3-5-10-8-9-4-1-2-6-11(9)14-13(10)12/h1-8,15H

Upstream product

• 90-04-0 2-methoxy-phenylamine 
• 6630-33-7 ortho-bromobenzaldehyde 
• 428848-28-6 4-ethoxyacridine 
• 108694-47-9 2'-methoxydiphenylamine-2-carboxaldehyde 
• 35308-00-0 4-methoxy-9(10H)-acridone 
• 3295-61-2 4-methoxyacridine 
• 578-07-4 4-aminoacridine 
• 16492-15-2 9-chloro-4-methoxyacridine 
• 155007-32-2 Acridine 3,4-oxide 

Downstream Products

• 1448453-99-3 C₃₄H₂₃N₃OPd 
• 578-07-4 4-aminoacridine 

Relevant articles and documents

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Synthesis and Solvolysis of Acridine 1,2- and 3,4-Oxides: Crystal Structure of Acridine 1,2-Oxide

Acridine 1,2- and 3,4-oxides were synthesized from 3,4- and 1,2-dihydroacridine, respectively, via intermediate bromohydrin acetates.Crystals of acridine 1,2-oxide were sufficiently stable to allow the first determination of X-ray crystallographic structu

NEUROLOGICALLY-ACTIVE COMPOUNDS

The present invention relates to neurologically-active compounds, being heterocyclic compounds having two fused 6-membered rings with a nitrogen atom at position 1 and a hydroxy or mercapto group at position 8 with at least one ring being aromatic. Also disclosed are processes for the preparation of these compounds and their use as pharmaceutical or veterinary agents, in particular for the treatment of neurological conditions, more specifically neurodegenerative conditions such as Alzheimer's disease.