181231-61-8

Basic information

• Product Name: [4-(4-methylphenoxy)phenyl]methanol
• Synonyms: [4-(4-methylphenoxy)phenyl]methanol;(4-(p-Tolyloxy)phenyl)methanol
• CAS NO: 181231-61-8
• Molecular Formula: C14H14O2
• Molecular Weight: 214.25976
• Mol File: 181231-61-8.mol
• Article Data: 2

Chemical Properties

• Appearance: /
• CAS DataBase Reference: [4-(4-methylphenoxy)phenyl]methanol(CAS DataBase Reference)
• NIST Chemistry Reference: [4-(4-methylphenoxy)phenyl]methanol(181231-61-8)
• EPA Substance Registry System: [4-(4-methylphenoxy)phenyl]methanol(181231-61-8)

Safety Data

• Statements: 41
• Safety Statements: 26-39
• Hazardous Substances Data: 181231-61-8(Hazardous Substances Data)

Usage

General Description

The chemical [4-(4-methylphenoxy)phenyl]methanol, also known as Methyl 4-(4-methylphenoxy)phenyl methanol, is an organic compound that belongs to the family of benzyl alcohols. It consists of a benzene ring with a methoxy group and a methyl group attached to it. [4-(4-methylphenoxy)phenyl]methanol is often used in pharmaceuticals and organic synthesis as a reagent and intermediate. It has potential applications in the production of various drugs, agrochemicals, and materials due to its unique structure and reactivity. Additionally, it is important to handle this chemical with care and in accordance with safety guidelines due to its potential hazardous properties.

Upstream product

• 106-44-5 p-cresol 

Relevant articles and documents

Discovery of Novel Cytochrome bc1 Complex Inhibitor Based on Natural Product Neopeltolide

Background: Natural products (NPs) are important sources for the design of new drugs and agrochemicals. Neopeltolide, a marine NP, has been identified as a potent Qo-site inhibitor of cytochrome bc1 complex. Methods: In this study, a series of neopeltolide derivatives was designed and synthesized by the simplification of its 14-membered macrolactone ring with a diphenyl ether fragment. The enzymatic inhibition bioassays and mycelium growth inhibition experiments against a range of fungi were performed to determine their fungicidal activities. Results: The derivatives have potent activity against the porcine bc1 complex. Compound 8q showed the best activity with an IC50 value of 24.41 nM, which was 8-fold more effective than that of positive control azoxystrobin. Compound 8a exhibited a 100% inhibitory rate against Zymoseptoria tritici and Alternaria solani at a 20 mg/L dose. Conclusion: Computational results indicated that compounds with suitable physicochemical properties, as well as those forming a hydrogen bond with His161, would have good fungicidal activity. These data could be useful for the design of bc1 complex inhibitors in the future.