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N-Boc-3-methyl-4-hydroxypiperidine is a versatile chemical compound with the molecular formula C11H21NO3. It is a piperidine derivative that features a tert-butoxycarbonyl (Boc) protecting group, a methyl group, and a hydroxy group attached to the piperidine ring. N-Boc-3-methyl-4-hydroxypiperidine plays a significant role in the field of medicinal chemistry due to its potential biological and pharmacological activities, as well as its applications in organic synthesis.

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  • 181269-70-5 Structure
  • Basic information

    1. Product Name: N-Boc-3-methyl-4-hydroxypiperidine
    2. Synonyms: N-Boc-3-methyl-4-hydroxypiperidine;4-Hydroxy-3-methyl-piperidine-1-carboxylic acid tert-butyl ester;tert-Butyl 4-hydroxy-3-Methylpiperidine-1-carboxylate;1-Piperidinecarboxylic acid, 4-hydroxy-3-Methyl-, 1,1-diMethylethylester;1-Boc4-hydroxy-3-Methylpiperidine
    3. CAS NO:181269-70-5
    4. Molecular Formula: C11H21NO3
    5. Molecular Weight: 215.291
    6. EINECS: N/A
    7. Product Categories: N/A
    8. Mol File: 181269-70-5.mol
  • Chemical Properties

    1. Melting Point: N/A
    2. Boiling Point: 301.4±35.0 °C(Predicted)
    3. Flash Point: N/A
    4. Appearance: /
    5. Density: 1.067
    6. Refractive Index: N/A
    7. Storage Temp.: Sealed in dry,Room Temperature
    8. Solubility: N/A
    9. PKA: 14.83±0.40(Predicted)
    10. CAS DataBase Reference: N-Boc-3-methyl-4-hydroxypiperidine(CAS DataBase Reference)
    11. NIST Chemistry Reference: N-Boc-3-methyl-4-hydroxypiperidine(181269-70-5)
    12. EPA Substance Registry System: N-Boc-3-methyl-4-hydroxypiperidine(181269-70-5)
  • Safety Data

    1. Hazard Codes: N/A
    2. Statements: N/A
    3. Safety Statements: N/A
    4. WGK Germany:
    5. RTECS:
    6. HazardClass: N/A
    7. PackingGroup: N/A
    8. Hazardous Substances Data: 181269-70-5(Hazardous Substances Data)

181269-70-5 Usage

Uses

Used in Pharmaceutical Industry:
N-Boc-3-methyl-4-hydroxypiperidine is used as a building block for the preparation of various pharmaceuticals. Its unique structure allows for the development of new drugs with specific therapeutic properties, making it an essential component in the synthesis of a wide range of medications.
Used in Agrochemical Industry:
In the agrochemical industry, N-Boc-3-methyl-4-hydroxypiperidine is utilized as a key intermediate in the synthesis of agrochemicals. Its presence in these compounds contributes to the effectiveness of pesticides, herbicides, and other agricultural products, enhancing crop protection and yield.
Used in Organic Synthesis:
N-Boc-3-methyl-4-hydroxypiperidine is used as a reagent in the synthesis of heterocyclic compounds and other organic molecules. Its versatility in organic synthesis allows for the creation of a diverse array of chemical products, including fine chemicals and specialty chemicals, which find applications in various industries.
Used in Medicinal Chemistry Research:
N-Boc-3-methyl-4-hydroxypiperidine has been studied for its potential biological and pharmacological activities. Researchers use this compound to explore its interactions with biological systems, which can lead to the discovery of new therapeutic agents and a better understanding of molecular mechanisms in medicine.

Check Digit Verification of cas no

The CAS Registry Mumber 181269-70-5 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 1,8,1,2,6 and 9 respectively; the second part has 2 digits, 7 and 0 respectively.
Calculate Digit Verification of CAS Registry Number 181269-70:
(8*1)+(7*8)+(6*1)+(5*2)+(4*6)+(3*9)+(2*7)+(1*0)=145
145 % 10 = 5
So 181269-70-5 is a valid CAS Registry Number.

181269-70-5SDS

SAFETY DATA SHEETS

According to Globally Harmonized System of Classification and Labelling of Chemicals (GHS) - Sixth revised edition

Version: 1.0

Creation Date: Aug 14, 2017

Revision Date: Aug 14, 2017

1.Identification

1.1 GHS Product identifier

Product name tert-butyl 4-hydroxy-3-methylpiperidine-1-carboxylate

1.2 Other means of identification

Product number -
Other names N-Boc-3-methyl-4-hydroxypiperidine

1.3 Recommended use of the chemical and restrictions on use

Identified uses For industry use only.
Uses advised against no data available

1.4 Supplier's details

1.5 Emergency phone number

Emergency phone number -
Service hours Monday to Friday, 9am-5pm (Standard time zone: UTC/GMT +8 hours).

More Details:181269-70-5 SDS

181269-70-5Relevant articles and documents

DUAL NAV1.2/5HT2A INHIBITORS FOR TREATING CNS DISORDERS

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Paragraph 0170, (2018/03/28)

Compounds of formula I: I are disclosed, as are pharmaceutical compositions containing such compounds. Methods of treating neurological or psychiatric disorders in a patient in need are also disclosed. Such disorders include depression, bipolar disorder, pain, schizophrenia, obsessive compulsive disorder, addiction, social disorder, attention deficit hyperactivity disorder, an anxiety disorder, autism, a cognitive impairment, or a neuropsychiatric symptom such as apathy, depression, anxiety, psychosis, aggression, agitation, impulse control disorders, and sleep disorders in neurological disorders such as Alzheimer's and Parkinson's diseases.

HEPATITIS B ANTIVIRAL AGENTS

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, (2013/07/05)

The present invention includes a method of inhibiting, suppressing or preventing HBV infection in an individual in need thereof, comprising administering to the individual a therapeutically effective amount of at least one compound of the invention.

THERAPEUTIC COMPOUNDS

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Paragraph 0625; 0626; 0627; 0628, (2014/01/07)

The present invention provides compounds of formula (I) and pharmaceutically acceptable salts thereof in which m, n, W, X, Y, Z, R, R1, R2, R3 and R4 are as defined in the specification, for use in therapy.

SULFONYL PIPERIDINE DERIVATIVES AND THEIR USE FOR TREATING PROKINETICIN MEDIATED DISEASES

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Page/Page column 56-57, (2014/01/07)

The present invention provides compounds of formula (I) and pharmaceutically acceptable salts thereof : (I) in which m, n, W, X, Y, Z, R1, R2, R3 and R4 are as defined in the specification, for use in the treatm

Piperdine derivatives useful as CCR3 antagonists

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Page/Page column 38, (2008/06/13)

The use of CCR3 antagonists of the formula I or a pharmaceutically acceptable salt thereof for the treatment of asthma is disclosed, as well as novel compounds of the formula II, pharmaceutical compositions comprising them, and their use in the treatment

HETEROARYLPIPERIDINE MODULATORS OF CHEMOKINE RECEPTOR ACTIVITY

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Page 74-75, (2008/06/13)

The present invention is directed to compounds of the formula (I): (wherein R>12345610 and n are defined herein) which are useful as modulators of chemokine receptor activity. In particular, these compounds are useful as modulators of the chemokine receptor CCR-2.

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