181280-07-9Relevant academic research and scientific papers
An efficient synthesis of benzopyrano-2-isoxazolines
Lee, Jong In,Lee, Hyo San,Kim, Byeang Hyean
, p. 3201 - 3215 (1996)
A series of benzopyrono-2-isoxazoline compounds have been prepared efficiently by three-step synthesis from corresponding salicylaldehyde derivatives.
Synthesis of Chromenoisoxazolidines from Substituted Salicylic Nitrones via Visible-Light Photocatalysis
Haun, Graham,Paneque, Alyson N.,Almond, David W.,Austin, Brooke E.,Moura-Letts, Gustavo
supporting information, p. 1388 - 1392 (2019/03/08)
This effort reports the first redox-neutral visible-light photocatalytic intramolecular dipolar cycloaddition for the diastereoselective synthesis of chromenoisoxazolidines. The authors have found that alkenylphenyl nitrones with a diverse substitution pattern on the aromatic ring and the alkenyl substituent undergo visible-light-promoted cycloadditions in the presence of catalytic amounts of Ru(bpy)3Cl2 in high yields and selectivities. Evidence indicates that the proposed redox-neutral pathway is the predominant photoredox mechanism for this transformation.
N-heterocyclic carbene-catalyzed hydroacylation of unactivated double bonds
Hirano, Keiichi,Biju, Akkattu T.,Piel, Isabel,Glorius, Frank
supporting information; experimental part, p. 14190 - 14191 (2010/02/15)
(Chemical Equation Presented) An intramolecular N-heterocyclic carbene (NHC)-catalyzed hydroacylation of unactivated double bonds is reported. Systematic variation of the catalyst structure revealed an N- mesitylthiazolylidene annulated with a seven-membered ring to be especially reactive. This NHC enables a unique C-C bond-forming reaction to afford substituted chroman-4-ones in moderate to excellent yields, even ones containing all-carbon quaternary centers.
