181284-94-6

Basic information

• Product Name: Ethyl 3-amino-4-methylbenzo[b]thiophene-2-carboxylate
• Synonyms: Ethyl 3-amino-4-methylbenzo[b]thiophene-2-carboxylate;3-Amino-4-methyl-benzo[b]thiophene-2-carboxylicacidethylester
• CAS NO: 181284-94-6
• Molecular Formula: C12H13NO2S
• Molecular Weight: 235.31
• Mol File: 181284-94-6.mol
• Article Data: 5

Chemical Properties

• Appearance: /
• CAS DataBase Reference: Ethyl 3-amino-4-methylbenzo[b]thiophene-2-carboxylate(CAS DataBase Reference)
• NIST Chemistry Reference: Ethyl 3-amino-4-methylbenzo[b]thiophene-2-carboxylate(181284-94-6)
• EPA Substance Registry System: Ethyl 3-amino-4-methylbenzo[b]thiophene-2-carboxylate(181284-94-6)

Safety Data

• Hazardous Substances Data: 181284-94-6(Hazardous Substances Data)

Upstream product

• 6575-09-3 2-chloro-6-methyl-benzonitrile 
• 623-51-8 ethyl 2-sulfanylacetate 
• 1885-76-3 2-cyano-3-nitrotoluene 

Downstream Products

• 1427420-56-1 C₂₁H₂₃NO₅S 

Relevant articles and documents

Synthesis and biological evaluation of 2-(alkoxycarbonyl)-3-anilinobenzo[b] thiophenes and thieno[2,3-b]pyridines as new potent anticancer agents

Two new series of inhibitors of tubulin polymerization based on the 2-(alkoxycarbonyl)-3-(3′,4′,5′-trimethoxyanilino)benzo[b] thiophene and thieno[2,3-b]pyridine molecular skeletons were synthesized and evaluated for antiproliferative activity on a panel

Benzimidazole derivative

The present invention is a thiobenzimidazole derivative represented by the following formula (1) or a medically acceptable salt thereof wherein said thiobenzimidazole derivative and a medically acceptable salt thereof have a potent activity of inhibiting human chymase. Thus, they are potential preventive and/or therapeutic agents clinically applicable to various diseases in which human chymase is involved.

BENZIMIDAZOLE DERIVATIVES

A benzimidazole derivative or its medically acceptable salt, represented by the following formula (1), that is a human chymase activity inhibitor capable of being applied clinically: wherein, R1 and R2 represent a hydrogen atom, an alkyl group or an alkoxy group, etc., A represents an alkylene group or an alkenylene group, E represents -COOR3, -SO3R3, -CONHR3 or -SO2NHR3, etc., G represents an alkylene group, M represents a single bond or -S(O)m-, J represents a heterocyclic group, and X represents -CH= or a nitrogen atom.