181297-91-6Relevant academic research and scientific papers
Design, synthesis and SAR of phenylamino-substituted 5,11-dihydro-dibenzo[a,d]cyclohepten-10-ones and 11H-dibenzo[b,f]oxepin-10-ones as p38 MAP kinase inhibitors
Dorn, Angelika,Schattel, Verena,Laufer, Stefan
scheme or table, p. 3074 - 3077 (2010/07/18)
The p38 MAP kinase is a key enzyme in inflammatory diseases as it is involved in the biosynthesis of proinflammatory cytokines such as TNF-α and IL-1β. Small molecule p38 inhibitors suppress the production of these cytokines and therefore p38 is a promisi
Anti-neurodegeneratively active 10-aminoaliphatyl-dibenzi ?b,f! oxepines
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, (2008/06/13)
Base-substituted debenz?b,f!oxepines of formula I STR1 wherein alk is a divalent aliphatic radical, R is an amino group that is unsubstituted or mono- or di-substituted by monovalent aliphatic and/or araliphatic radicals or disubstituted by divalent aliph
