181374-33-4

Upstream product

• 56844-38-3 2,4-dichloro-5-methylthieno[2,3-d]pyrimidine 
• 100-46-9 benzylamine 

Downstream Products

• 1080818-27-4 2-(pyrazol-1-yl)-5-methyl-4-benzylamino-thieno-[2,3-d]-pyrimidine 

Relevant academic research and scientific papers

Method for inhibiting neoplastic cells and related conditions by exposure thienopyrimidine derivatives

Benzothienopyrimidine derivatives for inducing or promoting apoptosis and for arresting uncontrolled neoplastic cell proliferation, and specifically for arresting and treating neoplasia, including precancerous and cancerous lesions of formula I: STR1 wherein R1 and R2 are independently selected from the group consisting of hydrogen, A, OA, alkenyl, alkynyl, --NO2, --CF3 or halogen, with the proviso that one of R1 or R2 is not hydrogen; R3 and R4 are independently selected from the group consisting of hydrogen, A, --OA, halogen, --NO2, --NH2, --NHA or --NAA', or R3 and R4 are together form a moiety selected from the group consisting of --O--CH2 --CH2 --, --O--CH2 --O-- or --O--CH2 --CH2 --O; X is selected from the group consisting of an unsubstituted or a substituted 5-7 membered saturated or unsaturated ring, wherein the ring is selected from the group consisting of phenyl, cyclopentyl, cyclohexyl, cycloheptyl, furyl, dioxolanyl, thienyl, pyrrolyl, pyrrolidinyl, imidazolyl, pyrazolyl, pyridyl, piperidinyl, morpholinyl, pyranyl, dioxanyl, pyridazinyl, pyrimidinyl, piperazinyl, quinolyl, and isoquinolyl and wherein the substitutents on the "X" ring are one or two selected from the group consisting of lower alkyl, COOH, --COOA, --CONH2, --CONAA', --CONHA, --CN, --CH2 COOH or --CH2 CH2 COOH; A and A' are independently selected from the group consisting of hydrogen or C1-6 alkyl; and n is 0, 1, 2 or 3; and physiologically acceptable salts thereof.

Thienopyrimidine with phosphodiesterase V inhibiting effect

PCT No. PCT/EP97/05530 Sec. 371 Date Jun. 11, 1999 Sec. 102(e) Date Jun. 11, 1999 PCT Filed Oct. 8, 1997 PCT Pub. No. WO98/17668 PCT Pub. Date Apr. 30, 1998The invention relates to thienopyrimidine of the formula (I) as well as to their physiologically ac

Method for inhibiting neoplastic cells and related conditions by exposure to thienopyrimidine derivatives

A method for inhibiting neoplastic cells and related conditions by exposing them to substituted thienopyrimidine compounds.