18144-47-3

Usage

Uses

Used in Pharmaceutical Industry:
Tert-Butyl 4-aminobenzoate is used as a local anesthetic for [application reason] pain relief by blocking sodium channels and preventing nerve impulses.
Used in Topical Medications:
Tert-Butyl 4-aminobenzoate is used as an active ingredient in topical medications for [application reason] providing pain relief and numbing the affected area.
Used in Ophthalmic Medications:
Tert-Butyl 4-aminobenzoate is used as an active ingredient in ophthalmic medications for [application reason] numbing the eye and providing relief from discomfort or pain.

InChI:InChI=1/C11H15NO2/c1-11(2,3)14-10(13)8-4-6-9(12)7-5-8/h4-7H,12H2,1-3H3

Upstream product

• 19756-72-0 tert-butyl 4-nitrobenzoate 
• 24537-25-5 4-sulfinylamino-benzoyl chloride 
• 75-65-0 tert-butyl alcohol 
• 62-23-7 4-nitro-benzoic acid 
• 150-13-0 4-amino-benzoic acid 
• 1257310-84-1 4-(2-trimethylsilanylethoxycarbonylamino)benzoic acid tert-butyl ester 
• 16106-38-0 4-aminobenzoyl chloride 
• 1370363-00-0 4-aminobenzoic acid tert-butyl ester hydrochloride 
• 769121-30-4 (4-acetylaminophenyl)carbamic acid tert-butyl ester 
• 59247-47-1 tert-butyl-4-bromobenzoate 
• 122-04-3 4-nitro-benzoyl chloride 

Downstream Products

• 94930-28-6 N-<4'-(tert-butoxycarbonyl)phenyl>-3-pyrrolidinol 
• 108292-73-5 Benzyl 2,3-Anhydro-4-<4-(tert-butyloxycarbonyl)phenylamino>-4-deoxy-β-L-lyxopyranoside 
• 108292-74-6 Benzyl 2,3-Anhydro-4-<4-(tert-butyloxycarbonyl)phenylamino>-4-deoxy-α-D-lyxopyranoside 
• 108292-75-7 Benzyl 2,3-Anhydro-4-<4-(tert-butyloxycarbonyl)phenylamino>-4-deoxy-β-L-ribopyranoside 
• 112888-76-3 tert-butyl p-[N-(prop-2-ynyl)amino]benzoate 
• 90906-55-1 t-butyl 4-<4-(dimethylamino)benzylideneamino>benzoate 
• 108947-99-5 6-<(p-carboxyanilino)methyl>-5-chloro-2,4-diaminoquinazoline tert-butyl ester 
• 301317-92-0 1-(4'-nitrophenyl)-3-(4''-tert-butylcarboxyphenyl)urea 
• 602307-42-6 4-selenocyanato-benzoic acid tert-butyl ester 
• 501169-57-9 tert-butyl 4-[N-(5-acetamido-6-bromoindan-1-yl)amino]benzoate 
• 716361-86-3 (E)-1-[3'-(4''-t-butylbenzoyl)benzamido-4'-benzyloxy]phenyl-2-(3''',5'''-dibenzyloxy)phenylethene 

Relevant academic research and scientific papers

Hydroboration reduction reaction of aromatic nitro compounds without transition metal catalysis

The invention relates to a hydroboration reduction reaction of aromatic nitro compounds without transition metal catalysis. According to the method, triethyl boron and potassium tert-butoxide are used as catalysts for the first time, and an aromatic nitro compound and pinacol borane which is low in price and easy to obtain can be conveniently catalyzed to be subjected to a hydroboration reduction reaction under mild conditions to prepare aromatic amine products. Compared with a traditional method, the method generally has the advantages that the catalyst is cheap and easy to obtain, operation is convenient, and reaction is safe. The selective hydroboration reduction reaction of the non-transition metal reagent catalyzed aromatic nitro compound and pinacol borane is realized for the first time, and a practical new reaction strategy is provided for laboratory preparation or industrial production of aromatic amine products.

Innovative Multipodal Ligands Derived from Tr?ger's Bases for the Sensitization of Lanthanide(III) Luminescence

Herein, the synthesis and characterization of the first family of multipodal ligands with a Tr?ger's base framework designed for the preparation of luminescent lanthanide(III) complexes are reported. Eight ligands were designed and synthesized using diffe

Synergistic effects in Fe nanoparticles doped with ppm levels of (Pd + Ni). A new catalyst for sustainable nitro group reductions

A remarkable synergistic effect has been uncovered between ppm levels of Pd and Ni embedded within iron nanoparticles that leads to mild and selective catalytic reductions of nitro-containing aromatics and heteroaromatics in water at room temperature. NaBH4 serves as the source of inexpensive hydride. Broad substrate scope is documented, along with several other features including: low catalyst loading, low residual metal in the products, and recycling of the catalyst and reaction medium, highlight the green nature of this new technology.

Carbonyl Iron Powder: A Reagent for Nitro Group Reductions under Aqueous Micellar Catalysis Conditions

An especially mild, safe, efficient, and environmentally responsible reduction of aromatic and heteroaromatic nitro-group-containing educts is reported that utilizes very inexpensive carbonyl iron powder (CIP), a highly active commercial grade of iron powder. These reductions are conducted in the presence of nanomicelles composed of TPGS-750-M in water, a recyclable aqueous micellar reaction medium. This new technology also shows broad scope and scalability and presents opportunities for multistep one-pot sequences involving this reducing agent.

SULFONAMIDE COMPOUNDS AND THEIR USE AS STAT5 INHIBITORS

The present disclosure relates to compounds having the Formula (Formula (I)) which are inhibitors of STAT5.

Chemoselective N-deacetylation under mild conditions

A mild and efficient chemoselective N-deacetylation using the Schwartz reagent at room temperature in rapid time is described. The mild and neutral conditions enable orthogonal N-deacetylation in the presence of some of the common protecting groups (viz. Boc, Fmoc, Cbz, Ts). The deprotection conditions did not induce any epimerization at the chiral amino centre.

Preparation of functionalized indoles and azaindoles by the intramolecular copper-mediated carbomagnesiation of ynamides

Variations on a theme: A mild and general intramolecular copper-mediated carbomagnesiation procedure for the synthesis of functionalized indoles as well as 4-, 5-, 6-, and 7-azaindoles starts from readily available ynamides. Subsequent reactions with various electrophiles provides polyfunctional N-heterocycles in good yields.

MATRIX METALLOPROTEINASE INHIBITORS

The present invention relates to methyl sulfonamides and N-formamides derivatives of formula (I) and to processes for their syntheses. The invention also relates to pharmacological compositions containing these derivatives and methods of treating asthma, rheumatoid arthritis, COPD, rhinitis, osteoarthritis, psoriatie arthritis, psoriasis, pulmonary fibrosis, pulmonary inflammation, acute respiratory distress syndrome, perodontitis, multiple sclerosis, gingivitis, atherosclerosis, dry eye, neointimal proliferation which leads to restenosis and ischemic heart failure, stroke, renal disease, tumor metastasis, and other inflammatory disorders characterized by over expression and over activation of an matrix metalloproteinase using the compounds.

Carbamic acid 2-trimethylsilylethyl ester as a new ammonia equivalent for palladium-catalyzed amination of aryl halides

Carbamic acid 2-trimethylsilylethyl ester (Teoc-NH2) serves as an ammonia equivalent in the palladium-catalyzed amination of aryl bromides and aryl chlorides. Anilines with sensitive functional groups can be readily prepared using these amine derivatives.

TARGETING PRODRUGS AND COMPOSITIONS FOR THE TREATMENT OF GASTROINTESTINAL DISEASES

Provided herein are compounds, compositions and methods for preventing or treating gastrointestinal cancer in a mammal, wherein the method comprises delivering an effective amount of a COX-2 or a similar sulfonamide inhibitor as a prodrug or derivative thereof to the colon, wherein the COX-2 or similar inhibitor is released in- vivo.