181481-48-1

Basic information

• Product Name: methyl 4-methoxy-2-nitrophenyl-α-cyanoacetate
• Synonyms: methyl 4-methoxy-2-nitrophenyl-α-cyanoacetate
• CAS NO: 181481-48-1
• Molecular Weight: 250.211
• Mol File: 181481-48-1.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: methyl 4-methoxy-2-nitrophenyl-α-cyanoacetate(CAS DataBase Reference)
• NIST Chemistry Reference: methyl 4-methoxy-2-nitrophenyl-α-cyanoacetate(181481-48-1)
• EPA Substance Registry System: methyl 4-methoxy-2-nitrophenyl-α-cyanoacetate(181481-48-1)

Safety Data

• Hazardous Substances Data: 181481-48-1(Hazardous Substances Data)

Downstream Products

• 147124-33-2 dimethyl 2-(4-methoxy-2-nitrophenyl)malonate 

Relevant articles and documents

Process for preparing 2-oxindoles and N-hydroxy-2-oxindoles

The present invention provides a processes, having practical utility, for preparing 2-oxindoles, N-hydroxy-2-oxindoles, or mixtures thereof comprising: catalytically hydrogenating a 2-nitroarylmalonate diester to produce a 2-(N-hydroxyamino)arylmalonate diester, a 2-aminoarylmalonate diester, or mixtures thereof as a first reaction intermediate; cyclizing, by intramolecular aminolysis of one ester group, the first reaction intermediate to produce a N-hydroxy-2-oxindole-3-carboxylate ester, 2-oxindole-3-carboxylate ester, or mixtures thereof as a second reaction intermediate; and hydrolyzing and decarboxylating the remaining ester group of the second reaction intermediate to produce the N-hydroxy-2-oxindole, the 2-oxindole, or mixtures thereof, wherein the cyclization reaction and the hydrolysis and decarboxylation reaction are conducted in situ with the catalytic hydrogenation reaction without isolation of said reaction intermediates.