181481-55-0 Usage
Explanation
The molecular formula represents the number of atoms of each element present in a molecule of the compound.
Explanation
Isocyanates are a class of organic compounds that contain an isocyanate functional group (N=C=O).
Explanation
The compound is utilized in the manufacturing of various materials due to its chemical properties.
Explanation
Exposure to isocyanates can cause irritation in the respiratory system and may lead to sensitization or allergic reactions in some individuals.
Explanation
To minimize health risks, it is essential to follow proper handling procedures and limit exposure to the compound during its use or production.
Type of compound
Isocyanate
Common uses
Production of polyurethane plastics, coatings, adhesives, and foams
Health risks
Potent respiratory irritant, sensitization, and allergic reactions
Safety precautions
Proper handling and limited exposure
Check Digit Verification of cas no
The CAS Registry Mumber 181481-55-0 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 1,8,1,4,8 and 1 respectively; the second part has 2 digits, 5 and 5 respectively.
Calculate Digit Verification of CAS Registry Number 181481-55:
(8*1)+(7*8)+(6*1)+(5*4)+(4*8)+(3*1)+(2*5)+(1*5)=140
140 % 10 = 0
So 181481-55-0 is a valid CAS Registry Number.
181481-55-0Relevant articles and documents
An asymmetric synthesis of L-694,458, a human leukocyte elastase inhibitor, via novel enzyme resolution of β-lactam esters
Cvetovich, Raymond J.,Chartrain, Michel,Hartner Jr., Frederick W.,Roberge, Christopher,Amato, Joseph S.,Grabowski, Edward J. J.
, p. 6575 - 6580 (1996)
A convergent synthesis of [S-(R*,S*)]-2-[4-[(4-methylpiperazin-1-yl)carbonyl]phenoxy]-3,3-diet hyl-N-[1-[3,4-(methylenedioxy)phenyl]butyl]-4-oxo-1-azetidinecarboxami de (L-694,458, 1), a potent human leukocyte elastase inhibitor, was achieved via chiral synthesis of key intermediates: (S)-3,3-diethyl-4-[4'-[(N-methylpiperazin-1-yl)carbonylphenoxy]-2-azet idinone (2) and (R)-α-propylpiperonyl isocyanate (3). Synthesis of β-lactam 2 was achieved by a novel enantioselective lipase hydrolysis of ester 5 to produce (S)-3,3-diethyl-4-(4'-carboxyphenoxy)-2-azetidinone (6) (60% yield, three cycles, 93% ee) with isolation, epimerization, and recycling of the undesired (R)-ester 5. Isocyanate 3 was prepared by chiral addition of Zn(n-Pr)2 to piperonal (98% yield, 99.2% ee), azide displacement and reduction to (R)-α-propylpiperonylamine (11) (58% yield, 85% ee), crystallization as the D-pyroglutamic acid salt (92% yield, 98.2% ee), and isocyanate formation (98% yield) with phosgene.
