181485-41-6

Basic information

• Product Name: 6-(4-Ethylthiazol-2-ylsulfanyl)-5-(methanesulfonamido)isobenzofuran-1(3H)-one
• Synonyms: L-758115; N-[6-(4-Ethylthiazol-2-ylsulfanyl)-1-oxo-1,3-dihydroisobenzofuran-5-yl]methanesulfonamide
• CAS NO: 181485-41-6
• Molecular Formula: C₁₄H₁₄N₂O₄S₃
• Molecular Weight: 370.47068
• Mol File: 181485-41-6.mol
• Article Data: 3

Chemical Properties

• CAS DataBase Reference: 6-(4-Ethylthiazol-2-ylsulfanyl)-5-(methanesulfonamido)isobenzofuran-1(3H)-one(CAS DataBase Reference)
• NIST Chemistry Reference: 6-(4-Ethylthiazol-2-ylsulfanyl)-5-(methanesulfonamido)isobenzofuran-1(3H)-one(181485-41-6)
• EPA Substance Registry System: 6-(4-Ethylthiazol-2-ylsulfanyl)-5-(methanesulfonamido)isobenzofuran-1(3H)-one(181485-41-6)

Safety Data

• Hazardous Substances Data: 181485-41-6(Hazardous Substances Data)

Upstream product

• 181485-49-4 4-ethyl-2-(3-methoxy-6-nitro-1,3-dihydro-isobenzofuran-5-ylsulfanyl)-thiazole 
• 181485-50-7 6-(4-ethyl-thiazol-2-ylsulfanyl)-5-nitro-1,3-dihydro-isobenzofuran-1-ol 
• 181485-51-8 6-(4-ethyl-2-thiazolylthio)-5-nitro-3H-isobenzofuran-1-one 
• 181485-52-9 5-Amino-6-(4-ethyl-2-thiazolylthio)-3H-isobenzofuran-1-one 
• 181485-45-0 2-acetoxymethyl-5-chloro-4-nitrobenzonitrile 
• 181485-47-2 6-chloro-5-nitro-1,3-dihydro-isobenzofuran-1-ol 
• 181485-46-1 6-chloro-5-nitro-3H-isobenzofuran-1-one 
• 181485-48-3 6-chloro-1-methoxy-5-nitro-1,3-dihydro-isobenzofuran 
• 101495-54-9 5-chloro-2-methyl-4-nitrobenzonitrile 
• 33120-75-1 2-mercapto-4-ethyl-thiazole 
• 181485-53-0 C₁₅H₁₆N₂O₆S₄ 

Relevant articles and documents

Method for the treatment and prevention of cachexia

Cachexia, including anorexia and other forms of weight loss, is a frequent complication of acute and chronic infections, and result from induction of cytokines, prostaglandins, and other inflammatory mediators that are critical for pathogen elimination. The present invention includes methods for the treatment or prevention of cachexic conditions while maintaining the production of factors essential for infection control through the administration of an effective amount of a cyclooxygenase-2 selective inhibiting compound.

Substituted heterocyclic analogs as selective COX-2 inhibitors in the flosulide class

Substituted heterocyclic analogs in the Flosulide class were investigated as potential selective cyclooxygenase-2 inhibitors. 6-(4-Ethyl- 2-thiazolylthio)-5-methanesulfonamido-3H-isobenzofuran-1-one 14 was found to be the optimal compound in the series wi