18150-94-2

Usage

Uses

Used in Pharmaceutical Industry:
3-Nitro-2-phenylthiophene is used as an intermediate in the synthesis of various pharmaceuticals for its ability to contribute to the development of complex chemical structures. Its aromatic properties and potential biological activities, such as anticancer properties, make it a valuable component in the creation of new drugs.
Used in Agrochemical Industry:
3-Nitro-2-phenylthiophene is utilized as an intermediate in the synthesis of agrochemicals, particularly in the development of pesticides and other agricultural chemicals. Its aromatic nature and potential antimicrobial properties contribute to the effectiveness of these products in protecting crops and enhancing agricultural productivity.
Used in Organic Synthesis:
3-Nitro-2-phenylthiophene is used as a key component in organic synthesis for the production of other complex chemicals. Its versatile chemical structure allows for various reactions and modifications, making it a valuable building block in the synthesis of a wide range of organic compounds.
Used in Chemical Research:
3-Nitro-2-phenylthiophene is studied for its potential biological activities, such as its anticancer and antimicrobial properties. Researchers are exploring its applications in the development of new therapeutic agents and understanding its interactions with biological systems to enhance its potential uses in various industries.

Upstream product

• 5153-67-3 nitrostyrene 
• 825-55-8 2-phenylthiophene 
• 108-24-7 acetic anhydride 
• 7697-37-2 nitric acid 

Relevant academic research and scientific papers

A one-pot synthesis of 3-nitrothiophene and 3-nitro-2-substituted thiophenes

A one-pot approach to the synthesis of 3-nitrothiophene and 3-nitro-2-substituted thiophenes has been developed. Exposure of 1,4-dithane-2,5-diol to nitroacetates or nitroalkenes in the presence of 25% triethylamine and subsequent treatment with molecular sieves and combinations of silica gel or acidic alumina with DDQ or chloranil formed 3-nitrothiophene or a number of 3-nitro-2-substituted thiophenes with complete regiocontrol. A simple work-up procedure removes the requirement for purification by chromatography for most post-synthetic applications.

Facile synthesis of 3-nitro-2-substituted thiophenes

A new approach to 3-nitro-2-substituted thiophenes has been developed. Exposure of commercially available 1,4-dithane-2,5-diol to nitroalkenes in the presence of 20% triethylamine results in a tandem Michael?intramolecular Henry reaction to form the corresponding tetrahydrothiophene. Subsequent microwave irradiation on acidic alumina in the presence of chloranil effects the solvent free dehydration and aromatization to form 3-nitro-2-substituted thiophenes cleanly and rapidly. A simple workup procedure removes the requirement for purification by chromatography in most cases.

A useful one-pot procedure for obtaining 2-aryl-5-nitrothiophenes from bromonitromethane and 3-aryl-3-chloro-propenals

A one-pot procedure was developed to prepare new 2-aryl-5-nitrothiophenes efficiently from bromonitromethane and 3-chloro-3-aryl-propenals. Nitrothiophenes were synthesized in good yields with a simple and easy workup procedure. Georg Thieme Verlag Stuttg

Substituted thiophene derivative and agricultural and horticultural fungicide containing the same as active ingredient

The substituted thiophene derivative of the invention which is represented by the general formula (1) has a broad disease spectrum for a pathogenic fungus of various crops, exhibits an excellent controlling effect on disease such as gray mold, powdery mil