181517-76-0

Downstream Products

• 951174-26-8 tert-butyl (3R,αS)-3-(3,4-methylenedioxyphenyl)-3-(N-benzyl-N-α-methylbenzylamino)propanoate 
• 911224-80-1 tert-butyl (3S,αR)-3-(N-benzyl-N-α-methylbenzylamino)-3-(piperon-3-yl)propanoate 
• 72071-75-1 (S)-3-amino-3-(piperon-3-yl)propanoic acid 
• 72071-75-1 (R)-3-amino-3-(piperon-3-yl)propanoic acid 

Relevant academic research and scientific papers

Epimerization of trans-3-arylaziridine-2-carboxylates at the C3 position

We describe here effective epimerization of trans to cis isomer of 1-benzyl-3-arylaziridine-2-carboxylates. The combination of samarium metal, iodine and N,N-dimethylaminoethanol promoted the epimerization of trans isomer to a ca. 1 : 1 mixture of cis and trans ones. Investigating more effective catalyst, indium chloride was found to afford a ca. 2 : 1 mixture of cis and trans isomers. Epimerization at benzylic position in the aziridines is suggested from the result with optically active ones. Preparation of cis-2-indolylaziridine towards construction of aziridinomitosene skeleton was achieved in this epimerization reaction.