181520-04-7

Upstream product

• 504-17-6 4,6-dihydroxy-2-mercaptopyrimidine 
• 5332-98-9 1,5-bis(2-chlorophenyl)-1,4-pentadien-3-one 
• 89-98-5 2-chloro-benzaldehyde 
• 5332-98-9 (1E,4E)-1,5-bis(2-chlorophenyl)-1,4-pentadiene-3-one 

Downstream Products

• 181520-32-1 7,11-Bis-(2-chloro-phenyl)-3-thioxo-2,4-diaza-spiro[5.5]undecane-1,5,9-trione 9-oxime 

Relevant academic research and scientific papers

7,11-diaryl-2,4-diazaspiro[5.5]undecane-1,5,9-triones: A new series of spiroheterocycles

A novel two step synthesis of 7,11-diaryl-2,4-diazaspiro[5.5]undecane-1,5,9-triones has been reported based on double Michael addition of 2-thiobarbiturates or N,N'-diaryl-2-thiobarbiturates with dibenzalacetones followed by reductive desulfurization with

Synthesis of 7,11-diaryl-3-oxo (or thioxo)-2,4-diazaspiro[5.5]undecane-1,5, 9-triones, Part I

Spiro compounds 7,11-diaryl-2,4-diazaspiro[5.5]undecane-1,3,5,9-tetraones 3a-e and 7,11-diaryl-3-thioxo-2,4-diazaspiro[5.5]undecane-1,5,9-triones 3f-j were prepared from the reaction of 1,5-diaryl-1,4-pentadien-3-ones 2a-f with barbituric acid (1a) and 2-

Synthesis and anticonvulsant activity of some spiro compounds derived from barbituric and thiobarbituric acids: Part I

Divinyl ketones (1), prepared by the condensation of acetone with the appropriate aromatic aldehydes, on Michael addition with barbituric and thiobarbituric acids afford the desired spiro compounds (2a-j). The ketoximes (3a-j) obtained from 2a-j on Beckmann transformation by treatment with PCl5 furnish the spiro azepines (4a-j). Alkylation of some of the compounds 2 afford the anticipated N-substituted products (5a-i). Preliminary pharmacological screening of some of the new compounds reveal their anticonvulsant activity.