181520-07-0Relevant academic research and scientific papers
Synthesis and anticonvulsant activity of some spiro compounds derived from barbituric and thiobarbituric acids: Part I
Osman,Kandeel,Said,Ahmed
, p. 1073 - 1078 (2007/10/03)
Divinyl ketones (1), prepared by the condensation of acetone with the appropriate aromatic aldehydes, on Michael addition with barbituric and thiobarbituric acids afford the desired spiro compounds (2a-j). The ketoximes (3a-j) obtained from 2a-j on Beckmann transformation by treatment with PCl5 furnish the spiro azepines (4a-j). Alkylation of some of the compounds 2 afford the anticipated N-substituted products (5a-i). Preliminary pharmacological screening of some of the new compounds reveal their anticonvulsant activity.
