181574-73-2Relevant academic research and scientific papers
Analogs of CC-1065 and the duocarmycins
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, (2008/06/13)
PCT No. PCT/US97/09076 Sec. 371 Date Sep. 7, 1999 Sec. 102(e) Date Sep. 7, 1999 PCT Filed May 30, 1997 PCT Pub. No. WO97/45411 PCT Pub. Date Dec. 4, 1997Analogs of antitumor antibiotics CC-1065 and the duocarmycins are synthesized which possess systematic
Synthesis, X-ray structure, and properties of fluorocyclopropane analogs of the duocarmycins incorporating the 9,9-difluoro-1,2,9,9a-tetrahydrocyclopropa[c]benzo[e]indol-4-one (F2CBI) alkylation subunit
Boger, Dale L.,Jenkins, Tracy J.
, p. 8860 - 8870 (2007/10/03)
The synthesis of 9,9-difluoro-1,2,9,9a-tetrahydrocyclopropa[c]benz[e]indol-4-one (F2CBI), a difluorocyclopropane analog of the CC-1065 and duocarmycin alkylation subunits which represents the first such agent containing substitution of the reac
