181582-01-4Relevant academic research and scientific papers
Synthesis of pyrazine C-ribosides via direct metalation
Liu, Weimin,Walker II, John A.,Chen, Jiong J.,Wise, Dean S.,Townsend, Leroy B.
, p. 5325 - 5328 (2007/10/03)
A direct metalation method has been developed for the synthesis of novel pyrazine C-nucleosides. The regiochemistry was controlled by selecting different substituents on the pyrazine ring and excellent stereoselectivity was achieved via a hydride delivery strategy. The scope and limitations of this method were studied. The uniquely designed 4b is a versatile synthon for the preparation of other pyrazine C-nucleosides.
