1816-92-8Relevant articles and documents
Concise syntheses of the 1,7-dihydropyrano[2,3-g]indole ring system of the stephacidins, aspergamides and norgeamides
Grubbs, Alan W.,Artman III, Gerald D.,Williams, Robert M.
, p. 9013 - 9016 (2005)
Three approaches towards the synthesis of the 1,7-dihydropyrano[2,3-g] indole ring system of the stephacidins, paraherquamides and norgeamides have been investigated. The first involves a tandem nitrene insertion/aromatic Claisen rearrangement. The second
FRET events in fluorescent pentapeptides containing aliphatic triazolo amino acid scaffolds: Role of spacer lengths
Bag, Subhendu Sekhar,Yashmeen, Afsana
, p. 171 - 183 (2019)
The FRET efficiencies in donor/acceptor pairs in the two termini of designed fluorescent pentapeptides depend on the flexibility of two arms of triazolyl amino acid scaffolds positioned in the center of the backbones inducing predominant β-sheet conformations. Flexible N-Terminus of the scaffold in a pentapeptide has led to higher FRET efficiency and makes it different from other peptide with flexible C-terminus.
A telescoped protocol for the synthesis of new pyrrolo [3,4-d]pyridazinones by cascade reactions
Bonacorso, Helio G.,Libero, Francieli M.,Dal Forno, Gean M.,Pittaluga, Everton P.,Porte, Liliane M.F.,Martins, Marcos A.P.,Zanatta, Nilo
, p. 5190 - 5195 (2015)
A new one-pot method, for the synthesis of polysubstituted pyrrolo[3,4-d]pyridazinones, is presented. The protocol consists in cascade reactions performed in the same media: (i) the thermal in situ pyrrole formation by the reaction of vinyl azides with 1,
Coumarin-based tripodal chemosensor for selective detection of Cu(II) ion and resultant complex as anion probe through a Cu(II) displacement approach
Sun, Jinzhi,Xu, Xiang,Yu, Guanghui,Li, Weina,Shi, Jinsheng
, p. 987 - 991 (2018)
In this paper, a novel tripodal fluorescent receptor based on naturally occurring coumarin was synthesized and its ionic recognition properties were fully investigated by spectroscopic techniques. As revealed by the results, tripodal 1 exhibits excellent selectivity toward copper(II) by forming a 1:1 complex with triazole N as the main binding sites. And the resulted 1·Cu2+ complex shows recognition ability toward H2PO4? by metal displacement approach. The recognition mechanism was further investigated by computer calculation.
Synthesis of Novel Pyrrolo[3,2- c ]carbazole and Dipyrrolo[3,2- c:2′,3′- g ]carbazole Derivatives
Sengul, Ibrahim Fazil,Astarci, Erhan,Kandemir, Hakan
, p. 1277 - 1281 (2016)
Pyrrolocarbazole and dipyrrolocarbazoles have been synthesized via the Hemetsberger indole synthesis, starting from 9-ethyl carbazole-3-carbaldehyde and 9-ethylcarbazole-3,6-dicarbaldeyde, respectively. The pyrrolocarbazole structures were confirmed through 1H NMR, 13C NMR, IR, mass spectrometry and single crystal X-ray diffraction techniques. The targeted compounds showed potent in vitro cytotoxicity against human colon cancer HT29 cells.
Bacterial versus human sphingosine-1-phosphate lyase (S1PL) in the design of potential S1PL inhibitors
Sanllehí, Pol,Abad, José-Luis,Casas, Josefina,Bujons, Jordi,Delgado, Antonio
, p. 4381 - 4389 (2016)
A series of potential active-site sphingosine-1-phosphate lyase (S1PL) inhibitors have been designed from scaffolds 1 and 2, arising from virtual screening using the X-ray structures of the bacterial (StS1PL) and the human (hS1PL) enzymes. Both enzymes ar
Design and synthesis of new 5-aryl-4-arylethynyl-1H-1,2,3-triazoles with valuable photophysical and biological properties
Efremova, Mariia M.,Govdi, Anastasia I.,Frolova, Valeria V.,Rumyantsev, Andrey M.,Balova, Irina A.
, (2021/05/28)
Cu-catalyzed 1,3-dipolar cycloaddition of methyl 2-azidoacetate to iodobuta-1,3-diynes and subsequent Suzuki-Miyaura cross-coupling were used to synthesize new triazoles derivatives: 5aryl-4-arylethynyl-1H-1,2,3-triazoles. Investigation of their optical p
Discovery of 4H-thieno[3,2-b]pyrrole derivatives as potential anticancer agents
Fang, Bo,Hu, Chunsheng,Ding, Yong,Qin, Hongxia,Luo, Yafei,Xu, Zhigang,Meng, Jiangping,Chen, Zhongzhu
, p. 1610 - 1627 (2021/06/06)
In this study, we describe the discovery of the 4H-thieno[3,2-b]pyrrole derivatives as an useful scaffold to obtain potent lead compounds for the treatment of colon cancer. We first started with the 4H-thieno[3,2-b]pyrrole derivatives which come from comp
A Bu4N[Fe(CO)3(NO)]-Catalyzed Hemetsberger–Knittel Indole Synthesis
Baykal, Aslihan,Plietker, Bernd
supporting information, (2020/02/20)
The nucleophilic Fe complex Bu4N[Fe(CO)3(NO)] (TBA[Fe]) catalyzes the direct intramolecular amination of aryl vinyl azides to give the corresponding indole derivatives in good to excellent yields.
