18163-47-8 Usage
Physical properties
bp 96 °C, 55 °C/20 mmHg; n20
D 1.5110;
d 1.46 g cm?3, fp 48°C.
Uses
Different sources of media describe the Uses of 18163-47-8 differently. You can refer to the following data:
1. (Iodoethynyl)trimethylsilane is widely used as alkyne coupling reagent predominantly used in conjunction with
organocopper species or palladium catalysis.(Iodoethynyl)trimethylsilane has been largely
confined to aryl- and vinylcopper coupling, where it serves well
since the reverse procedure, i.e. coupling with alkynylcopper
reagents, is not straightforward due to the lack of reactivity of
alkynyl moieties bound to copper.
2. 1-Iodo-2-(trimethylsilyl)acetylene may be used to investigate the reactivity of diamagnetic cobalt(I) complex, Tol-BDI((2-pp)2)Co [Tol-BDI((2-pp)2)H = 2-(4-tolyl)-1,3-bis(2-isopropylpyridyl)propenediimine]. It may be used for the synthesis of 1-(4-trimethylsilanylbuta-1,3-diynyl)pyrene, via Pd-coupling with 1-iodo-2-trimethylsilylacetylene.
Preparation
All involve iodination of trimethylsilylacetylenes.
Direct iodination of metalated (lithium or magnesium)
trimethylsilylacetylene has been largely supplanted
due to the modest yields obtained. Utilizing trimethylsilylacetylene
and bis(trimethylsilyl) peroxide in the presence
of copper(I) iodide gives good yields. Substituting zinc
iodide requires using the lithium acetylide. Copper(I) iodide
(0.05 equiv.) in the presence of iodine, sodium carbonate, and
a phase-transfer catalyst gives good yields without having to
use n-butyllithium or a Grignard reagent to first deprotonate
the trimethylsilylacetylene. The most popular procedure uses
bis(trimethylsilyl)acetylene, treating it with iodine monochloride
in dichloromethane at 25°Cto obtain excellent yields of
(iodoethynyl)trimethylsilane.
Check Digit Verification of cas no
The CAS Registry Mumber 18163-47-8 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 1,8,1,6 and 3 respectively; the second part has 2 digits, 4 and 7 respectively.
Calculate Digit Verification of CAS Registry Number 18163-47:
(7*1)+(6*8)+(5*1)+(4*6)+(3*3)+(2*4)+(1*7)=108
108 % 10 = 8
So 18163-47-8 is a valid CAS Registry Number.
InChI:InChI=1/C5H9ISi/c1-7(2,3)5-4-6/h1-3H3
18163-47-8Relevant articles and documents
Copper(I)- and Phase Transfer-Catalysed Iodination of Terminal Alkynes
Jeffery, Tuyet
, p. 909 - 910 (1988)
A convenient synthesis of 1-iodoalk-1-ynes is reported, involving cooper(I)-catalysed iodination of terminal alkynes with molecular iodine under solid-liquid phase-transfer conditions.
SIRT1 Receptor agonists and drugs containing same
-
Paragraph 0110-0111; 0116; 0144-0145; 0147, (2021/10/13)
The present invention belongs to the field of medicaments or nutraceutical products, and specifically relates to a compound represented by the following general formula (I), or an enantiomer, diastereomer, salt, ester, prodrug, solvate, or solvate of a salt thereof, wherein R1, R2, and R3 are as defined in the specification of the present invention. The compound prepared by the present invention brings about an effect of activating Sirt1, and can be used as a potential Sirt1 agonist. By using a hyperuricemia animal model, the compound of the present invention is found to bring about an effect of significantly lowering the level of uric acid in the body, and can be used as a potential medicament for lowering the level of uric acid or treating gout.
Synthesis and reactions of a new 1,1-disubstituted cyclopentadiene
Camps, Pelayo,Gómez, Tània
scheme or table, p. 128 - 139 (2011/05/12)
The synthesis and several synthetic transformations of methyl 1-benzylcyclopenta-2,4-diene-1-carboxylate are described. ARKAT USA, Inc.
An alkynyliodide cycloaddition strategy for the construction of iodoisoxazoles
Crossley, James A.,Browne, Duncan L.
supporting information; scheme or table, p. 5414 - 5416 (2010/10/04)
(Figure presented) The thermally promoted cycloaddition between alkynyliodides and nitrile oxides is reported. The process offers excellent regioselectivity and a broad scope with respect to both the iodoalkynes and chloro-oximes. Further functionalization of the highly decorated iodoisoxazole motifs can be achieved via Suzuki cross-coupling.
