181656-27-9Relevant academic research and scientific papers
A general route to 5-substituted-2-furylacetic acids: a brief synthesis of plakorsin B
Hayes, Simon J.,Knight, David W.,Smith, Andrew W.T.,O'Halloran, Mark J.
, p. 717 - 719 (2010)
3,4-Dihydroxy-5-alkynylcarboxylic acids, readily obtained by the addition of lithium acetylides to α-acetoxysuccinic anhydride followed by reduction and hydrolysis, undergo smooth silver(I)-catalysed 5-endo-dig cyclisations and in situ dehydration to give excellent overall yields of 5-substituted-2-furylacetic acids, including the natural metabolite plakorsin B.
