181657-56-7

Basic information

• Product Name: (1R,2R)-(-)-2-Benzyloxycyclopentylamine
• Synonyms: (1R-TRANS)-2-(PHENYLMETHOXY)CYCLOPENTANEAMINE;(1R,2R)-(-)-2-BENZYLOXYCYCLOPENTYLAMINE;(1R,2R)-2-BENZYLOXYCYCLOPENTYLAMINE;(1R,2R)-1-Amino-2-benzyloxycyclopentane~(1R-trans)-2-(Phenylmethoxy)cyclopentanamine;(1r,2r)-1-amino-2-benzyloxycyclopentane;(1r-trans)-2-(phenylmethoxy)cyclopentanamine;(1R,2R)-(-)-2-BENZYLOXYCYCLOPENTYLAMINE, CHIPROS 99+%, EE 98;[1R,2R]-trans-2-Benzyl-oxycyclopentylamine
• CAS NO: 181657-56-7
• Molecular Formula: C12H17NO
• Molecular Weight: 191.27
• EINECS: -0
• Mol File: 181657-56-7.mol
• Article Data: 4

Chemical Properties

• Melting Point: 23℃
• Boiling Point: 90-93°C 0,23mm
• Flash Point: >110°C
• Appearance: /
• Density: 0.983
• Vapor Pressure: 0.002mmHg at 25°C
• Refractive Index: 1.5305
• Storage Temp.: 2-8°C
• PKA: 10.11±0.40(Predicted)
• Water Solubility: Not miscible or difficult to mix with water.
• Sensitive: Air Sensitive
• CAS DataBase Reference: (1R,2R)-(-)-2-Benzyloxycyclopentylamine(CAS DataBase Reference)
• NIST Chemistry Reference: (1R,2R)-(-)-2-Benzyloxycyclopentylamine(181657-56-7)
• EPA Substance Registry System: (1R,2R)-(-)-2-Benzyloxycyclopentylamine(181657-56-7)

Safety Data

• Hazard Codes: C
• Statements: 34-21/22
• Safety Statements: 26-36/37/39-45
• RIDADR: 2735
• WGK Germany: 3
• HazardClass: 8
• PackingGroup: III
• Hazardous Substances Data: 181657-56-7(Hazardous Substances Data)

Usage

Uses

(1R,2R)-(-)-2-Benzyloxycyclopentylamine is an important raw material and intermediate used in organic synthesis, pharmaceuticals, agrochemicals and dyestuff field.

InChI:InChI=1/C12H17NO/c13-11-7-4-8-12(11)14-9-10-5-2-1-3-6-10/h1-3,5-6,11-12H,4,7-9,13H2/t11-,12-/m1/s1

Upstream product

• 113625-73-3 rel-(1R,2R)-2-(benzyloxy)-1-cyclopentanol 
• 100-44-7 benzyl chloride 
• 663926-33-8 (1R,2S)-2-(2-hydroxy-cyclopentyl)-isoindole-1,3-dione 
• 663926-34-9 (1S,2R)-2-(2-benzyloxy-cyclopentyl)-isoindole-1,3-dione 

Downstream Products

• 33092-86-3 trans-2-aminocyclopentanol 
• 1330069-67-4 trans-N-(2-hydroxycyclopentyl)carbamic acid tert-butyl ester 
• 445479-01-6 (1R,2S)-2-tert-Butoxycarbonylaminocyclopentylamine 
• 145106-43-0 (1S,2S)-trans-2-(tert-butoxycarbonylamino)cyclopentanol 
• 415897-72-2 [2-hydroxy-2-(4-phenoxyphenyl)cyclopentyl][(methylethyl)sulfonyl]amine 
• 415897-64-2 cis-[2-fluoro-2-(4-phenylphenyl)cyclopentyl][(methylethyl)sulfonyl]amine 

Relevant articles and documents

Hybrid Organo- and Biocatalytic Process for the Asymmetric Transformation of Alcohols into Amines in Aqueous Medium

A hybrid organo- and biocatalytic system for the asymmetric conversion of racemic alcohols into amines was developed. Combining an organocatalyst, AZADO, an oxidant, NaOCl, and an enzyme, ω-transaminase, we implemented a one-pot oxidation-transamination sequential process in aqueous medium. The method showed broad substrate scope and was successfully applied to conventional secondary alcohols and sterically hindered β-substituted cycloalkanols, where a highly stereoselective dynamic asymmetric bioamination enabled us to set up both contiguous stereocenters with very high enantio- and diastereomeric ratio (>90% yield, >99% ee, and up to 49:1 dr).

COMBINATION OF BENZOTHIAZOL-2-ONE BETA2 ADRENOCEPTOR AGONISTS AND CORTICOSTEROIDS FOR THE TREATMENT OF RESPIRATORY DISEASES

A medicament comprising, separately or together, (A) a compound of Formula (I) in free or salt or solvate form, wherein X has the meaning as indicated in the specification; and (B) a corticosteroid, for simultaneous, sequential or separate administration in the treatment of an inflammatory obstructive airways disease, the molar ratio of (A) to (B) being from 100:1 to 1:300.