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Cyclopiazonic acid (CPA) is a mycotoxin and a tetramic acid that is synthesized by various Aspergillus and Penicillium species. It is a highly specific inhibitor of calcium ATPase of sarcoplasmic reticulum, altering calcium homeostasis and ATP-dependent calcium transport, resulting in the release of intracellular stored Ca2+ without increasing IP3. Cyclopiazonic acid is an off-white powder or crystals.

18172-33-3

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18172-33-3 Usage

Uses

Used in Pharmaceutical Industry:
Cyclopiazonic acid is used as a standard in aflatoxin detection and quantification by thin layer chromatography (TLC). It is also used as a reversible inhibitor of the sarco/endoplasmic reticulum Ca2+-ATPase (SERCA) to examine the role of luminal calcium in endoplasmic reticulum (ER)-to-Golgi trafficking.
Used in Research:
Cyclopiazonic acid is used as an endoplasmic reticulum Ca2+-ATPase blocker to treat neurons and study the role of the endoplasmic reticulum (ER) in releasing and sustaining Ca2+ during Ca2+-induced Ca2+ release (CICR). It is also used to inhibit SERCA.
Used in Cardiology:
In Langendorff-perfused murine hearts, cyclopiazonic acid has displayed anti-arrhythmic effects.
Used in Physiology Research:
Administration of cyclopiazonic acid on rat soleus muscle has shown a decrease in hormone-sensitive lipase activity and triacylglycerol hydrolysis.

Biological Activity

Cell-permeable, reversible inhibitor of sarcoplasmic reticulum Ca 2+ -ATPase.

Biochem/physiol Actions

Inhibits the sarcoplasmic reticulum Ca2+-pump.

Check Digit Verification of cas no

The CAS Registry Mumber 18172-33-3 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 1,8,1,7 and 2 respectively; the second part has 2 digits, 3 and 3 respectively.
Calculate Digit Verification of CAS Registry Number 18172-33:
(7*1)+(6*8)+(5*1)+(4*7)+(3*2)+(2*3)+(1*3)=103
103 % 10 = 3
So 18172-33-3 is a valid CAS Registry Number.

18172-33-3 Well-known Company Product Price

  • Brand
  • (Code)Product description
  • CAS number
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  • Sigma

  • (C1530)  Cyclopiazonic acid from Penicillium cyclopium  ≥98% (HPLC), powder

  • 18172-33-3

  • C1530-5MG

  • 978.12CNY

  • Detail

  • Sigma

  • (C1530)  Cyclopiazonic acid from Penicillium cyclopium  ≥98% (HPLC), powder

  • 18172-33-3

  • C1530-10MG

  • 1,698.84CNY

  • Detail

  • Sigma

  • (C1530)  Cyclopiazonic acid from Penicillium cyclopium  ≥98% (HPLC), powder

  • 18172-33-3

  • C1530-50MG

  • 6,154.20CNY

  • Detail

18172-33-3SDS

SAFETY DATA SHEETS

According to Globally Harmonized System of Classification and Labelling of Chemicals (GHS) - Sixth revised edition

Version: 1.0

Creation Date: Aug 14, 2017

Revision Date: Aug 14, 2017

1.Identification

1.1 GHS Product identifier

Product name (6aR,11aS,11bR)-10-acetyl-11-hydroxy-7,7-dimethyl-2,6,6a,7,11a,11b-hexahydro-9H-pyrrolo[1',2':2,3]isoindolo[4,5,6-cd]indol-9-one

1.2 Other means of identification

Product number -
Other names PENICILLIUM CYCLOPIUM

1.3 Recommended use of the chemical and restrictions on use

Identified uses For industry use only.
Uses advised against no data available

1.4 Supplier's details

1.5 Emergency phone number

Emergency phone number -
Service hours Monday to Friday, 9am-5pm (Standard time zone: UTC/GMT +8 hours).

More Details:18172-33-3 SDS

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