18174-72-6 Usage
Uses
Used in Pharmaceutical Research:
Muscimol Hydrate is used as a research chemical for studying the GABA-A receptor and its role in the central nervous system. It helps researchers understand the mechanisms of action of GABA and develop new therapeutic agents for neurological disorders.
Used in Neurological Research:
Muscimol Hydrate is used as a neurochemical tool in the investigation of the GABAergic system, which plays a crucial role in regulating neuronal excitability and inhibiting neurotransmitter release. It aids in understanding the pathophysiology of various neurological conditions, such as epilepsy, anxiety, and depression.
Used in Drug Development:
Muscimol Hydrate is used as a lead compound in the development of new drugs targeting the GABA-A receptor. Its potent agonistic activity allows researchers to explore its potential therapeutic applications and design safer and more effective drugs for the treatment of neurological disorders.
Used in Toxicological Studies:
Due to its potent and toxic nature, Muscimol Hydrate is used in toxicological research to study the effects of GABA-A receptor agonists on the central nervous system. This helps in understanding the risks and side effects associated with the use of such compounds and contributes to the development of safer therapeutic agents.
Biochem/physiol Actions
Muscimol hydrobromide is a GABAA receptor agonist.
References
1) Akhondzadeh et al. (1995), Induction of a novel form of hippocampal long-term depression by muscimol: involvement of GABAA but not glutamate receptors; Br. J. Pharmacol., 115 527
Check Digit Verification of cas no
The CAS Registry Mumber 18174-72-6 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 1,8,1,7 and 4 respectively; the second part has 2 digits, 7 and 2 respectively.
Calculate Digit Verification of CAS Registry Number 18174-72:
(7*1)+(6*8)+(5*1)+(4*7)+(3*4)+(2*7)+(1*2)=116
116 % 10 = 6
So 18174-72-6 is a valid CAS Registry Number.
InChI:InChI=1/C4H6N2O2.BrH/c5-2-3-1-4(7)6-8-3;/h1H,2,5H2,(H,6,7);1H
18174-72-6Relevant academic research and scientific papers
4,5-Substituted 3-Isoxazolols with Insecticidal Activity Act as Competitive Antagonists of Housefly GABA Receptors
Liu, Genyan,Ozoe, Fumiyo,Furuta, Kenjiro,Ozoe, Yoshihisa
, p. 6304 - 6312 (2015/08/03)
The insect GABA receptor (GABAR), which is composed of five RDL subunits, represents an important target for insecticides. A series of 4,5-disubstituted 3-isoxazolols, including muscimol analogues, were synthesized and examined for their activities agains
