181758-85-0Relevant academic research and scientific papers
Structure-anti-MRSA activity relationship of macrocyclic bis(bibenzyl) derivatives
Sawada, Hiromi,Onoda, Kenji,Morita, Daichi,Ishitsubo, Erika,Matsuno, Kenji,Tokiwa, Hiroaki,Kuroda, Teruo,Miyachi, Hiroyuki
, p. 6563 - 6568 (2014/01/06)
We synthesized a series of macrocyclic bis(bibenzyl) derivatives, including riccardin-, isoplagiochin- and marchantin-class structures, and evaluated their antibacterial activity towards methicillin-resistant Staphylococcus aureus (anti-MRSA activity). Th
Co-existence of α-glucosidase-inhibitory and liver X receptor-regulatory activities and their separation by structural development
Dodo, Kosuke,Aoyama, Atsushi,Noguchi-Yachide, Tomomi,Makishima, Makoto,Miyachi, Hiroyuki,Hashimoto, Yuichi
, p. 4272 - 4285 (2008/09/21)
Liver X receptors (LXR), which were originally reported as oxysterol-activated nuclear receptors, were recently found to recognize glucose as a physiological ligand. On this basis, we have already developed novel LXR antagonists based upon α-glucosidase i
Total synthesis of cavicularin and riccardin C: Addressing the synthesis of an arene that adopts a boat configuration
Harrowven, David C.,Woodcock, Timothy,Howes, Peter D.
, p. 3899 - 3901 (2007/10/03)
(Chemical Equation Presented) A transannular ring contraction induced by the addition of an aryl radical intermediate to a proximal arene facilitated the construction of the highly strained macrocyclic core of cavicularin (1). The precursor, an iodinated
