181761-60-4

Basic information

• Product Name: tert-Butyl Methyl(2-(2,2,2-trifluoroacetaMido)ethyl)carbaMate
• Synonyms: tert-Butyl Methyl(2-(2,2,2-trifluoroacetaMido)ethyl)carbaMate
• CAS NO: 181761-60-4
• Molecular Formula: C10H17F3N2O3
• Molecular Weight: 270.2487896
• Mol File: 181761-60-4.mol
• Article Data: 3

Chemical Properties

• Appearance: /
• CAS DataBase Reference: tert-Butyl Methyl(2-(2,2,2-trifluoroacetaMido)ethyl)carbaMate(CAS DataBase Reference)
• NIST Chemistry Reference: tert-Butyl Methyl(2-(2,2,2-trifluoroacetaMido)ethyl)carbaMate(181761-60-4)
• EPA Substance Registry System: tert-Butyl Methyl(2-(2,2,2-trifluoroacetaMido)ethyl)carbaMate(181761-60-4)

Safety Data

• Hazardous Substances Data: 181761-60-4(Hazardous Substances Data)

Upstream product

• 24424-99-5 di-tert-butyl dicarbonate 
• 109-81-9 N-methyl-ethane-1,2-diamine 
• 172657-58-8 2,2,2-trifluoro-N-(2-(methylamino)ethyl)acetamide 

Relevant articles and documents

Design, synthesis, and biological activity of a novel non-cisplatin-type platinum-acridine pharmacophore

Platinum-acridine conjugates were prepared from [PtCl2(ethane-1,2-diamine)] and the novel acridinylthioureas MeHNC(S)NMeAcr (6) and MeHNC(S)NMe(CH2CH2)NHAcr (15) by replacing one chloro leaving group in the cisplatin analogue with thiourea sulfur. In HL-60 leukemia cells, IC50 values for 7 (Pt-tethered 6) and 16 (Pt-tethered 15) were 75 and 0.13 μM, respectively. In the ovarian cell lines 2008 and C13*, 16 was active at micromolar concentrations and showed only partial cross-resistance with clinical cisplatin. Possible structure-activity relationships are discussed.

CARBAPENEM ANTIBACTERIALS WITH GRAM-NEGATIVE ACTIVITY AND PROCESSES FOR THEIR PREPARATION

The present invention provides β-methyl carbapenem compounds and pharmaceutical compositions useful in the treatment of bacterial infections and methods for treating such infections using such compounds and/or compositions. The invention includes administ