1817735-35-5

Basic information

• Product Name: 1,1,1-Trifluoroethyl-PEG4-azide
• Synonyms: 1,1,1-Trifluoroethyl-PEG4-azide
• CAS NO: 1817735-35-5
• Molecular Formula: C10H18F3N3O4
• Molecular Weight: 301.27
• Mol File: 1817735-35-5.mol
• Article Data: 0

Chemical Properties

• Appearance: /
• CAS DataBase Reference: 1,1,1-Trifluoroethyl-PEG4-azide(CAS DataBase Reference)
• NIST Chemistry Reference: 1,1,1-Trifluoroethyl-PEG4-azide(1817735-35-5)
• EPA Substance Registry System: 1,1,1-Trifluoroethyl-PEG4-azide(1817735-35-5)

Safety Data

• Hazardous Substances Data: 1817735-35-5(Hazardous Substances Data)

Usage

Description

1,1,1-Trifluoroethyl-PEG4-azide is a versatile crosslinker that features an azide group for Click Chemistry, a hydrophilic PEG4 spacer for enhanced solubility in aqueous environments, and a trifluoroethyl group for selective reactivity with primary amine groups in proteins, antibodies, and other molecules and surfaces.

Uses

Used in Bioconjugation:
1,1,1-Trifluoroethyl-PEG4-azide is used as a bioconjugation agent for the selective attachment of proteins, antibodies, and other molecules to surfaces or other biomolecules. The trifluoroethyl group reacts with primary amine groups, enabling stable and specific conjugation.
Used in Drug Delivery Systems:
1,1,1-Trifluoroethyl-PEG4-azide is used as a component in drug delivery systems to improve the solubility and stability of therapeutic agents. The hydrophilic PEG4 spacer enhances the solubility of hydrophobic drugs, while the azide group allows for Click Chemistry-based modifications and functionalizations.
Used in Surface Modification:
1,1,1-Trifluoroethyl-PEG4-azide is used for modifying surfaces, such as in the development of biosensors or lab-on-a-chip devices. The trifluoroethyl group can react with amine-functionalized surfaces, allowing for the covalent attachment of proteins, antibodies, or other biomolecules for specific applications.
Used in Click Chemistry:
1,1,1-Trifluoroethyl-PEG4-azide is used as a Click Chemistry reagent for the rapid and efficient formation of stable triazole linkages between molecules. The azide group participates in copper-catalyzed azide-alkyne cycloaddition (CuAAC) reactions, enabling the precise and modular assembly of complex molecular structures.