181780-45-0Relevant academic research and scientific papers
Parallel synthesis and cytotoxicity evaluation of a polyamine-quinone conjugates library
Bolognesi, Maria Laura,Calonghi, Natalia,Mangano, Chiara,Masotti, Lanfranco,Melchiorre, Carlo
, p. 5463 - 5467 (2008)
A library of 24 derivatives designed by combining two natural products-derived fragments was prepared and tested to determine their anticancer potential in HT29 colon cancer cells. All library members inhibit cell proliferation as measured by MTT mitochondrial functional assay, with IC 50 values in the 1-100 μM range. Entry 1b caused apoptotic EGFR-mediated intracellular signaling. Thus, polyamino-quinones emerged as readily accessible and easily diversified scaffolds for anticancer lead discovery.
Synthesis of Carbamate Protected Spermidine Homologues Through α,ω-Alkanediamines
Arasujo, M. Joso S. M. P.,Ragnarsson, Ulf,Trigo, M. Joaquina S. A. Amaral,Almeida, M. Lurdes S.
, p. 2143 - 2161 (2007/10/03)
The total synthesis of three triamines selectively protected in the primary amino groups (1a-c) and two triamines protected in the secondary amino function and in one of the primary amino functions (2a and 2c), based on a simple and efficient procedure, is described.
