181786-86-7

Upstream product

• 181637-33-2 N-[(1R,3R)-4-(tert-Butyl-diphenyl-silanyloxy)-1-furan-2-yl-3-hydroxy-butyl]-4-methyl-benzenesulfonamide 
• 181637-30-9 N-((1R,3R)-1-Furan-2-yl-3,4-dihydroxy-butyl)-4-methyl-benzenesulfonamide 
• 58479-61-1 tert-butylchlorodiphenylsilane 
• 501-53-1 benzyl chloroformate 
• 181637-36-5 [(1R,3R)-4-(tert-Butyl-diphenyl-silanyloxy)-1-furan-2-yl-3-hydroxy-butyl]-carbamic acid benzyl ester 

Downstream Products

• 132970-48-0 ((3R,5R)-5-Hydroxymethyl-2-oxo-tetrahydro-furan-3-yl)-carbamic acid benzyl ester 

Relevant academic research and scientific papers

A facile transformation of the δ-hydroxy-α-amino lactones from α- furfuryl amide

(S)- and (R)- α- furfuryl amides, obtained from the kinetic resolution of (R, S)- α- furfuryl amide using the modified Sharpless asymmetric epoxidation, have been transformed into four 8-hydroxy α- amino lactones (1S, 3S)-1, (1R, 3R)-1, (1S, 3R)-1, (1R, 3S)-1, using sharpless asymmetric dihydroxylation as the key step. The much more efficient method of the addition of chiral aldimine 10 with allylic Grignard reagent for preparation of (S, S)-1 was also achieved.

A new approach to clavalanine β-lactam antibiotic: Transformation of chiral α-furfuryl amide into the δ-hydroxyl-α-amino lactones via asymmetrical dihydroxylation

Transformation of chiral α-furfuryl amide obtained from kinetic resolution into four δ-hydroxyl-α-amino lactones by utilizing the Sharpless ADH reaction as a key step was achieved.