SPDP-PEG6-NHS ester is a PEG (polyethylene glycol) linker with SPDP (N-succinimidyl 3-(2-pyridyldithio)propionate) and NHS (N-hydroxysuccinimide) ester moieties. The SPDP serves as an amine and thiol reactive crosslinker, which is membrane permeable, enabling it to engage in intracellular crosslinking reactions. The NHS ester is amine reactive and can form stable amide bonds. The hydrophilic PEG linker enhances the solubility of the compound in aqueous media, making it a versatile molecule for various applications.
1818294-32-4
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Basic information
- Product Name: SPDP-PEG6-NHS ester
- Synonyms: SPDP-PEG6-NHS ester
- CAS NO:1818294-32-4
- Molecular Formula: C27H41N3O11S2
- Molecular Weight: 647.75794
- EINECS: N/A
- Product Categories: N/A
- Mol File: 1818294-32-4.mol
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Chemical Properties
- Melting Point: N/A
- Boiling Point: N/A
- Flash Point: N/A
- Appearance: /
- Density: N/A
- Refractive Index: N/A
- Storage Temp.: N/A
- Solubility: Soluble in DCM
- CAS DataBase Reference: SPDP-PEG6-NHS ester(CAS DataBase Reference)
- NIST Chemistry Reference: SPDP-PEG6-NHS ester(1818294-32-4)
- EPA Substance Registry System: SPDP-PEG6-NHS ester(1818294-32-4)
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Safety Data
- Hazard Codes: N/A
- Statements: N/A
- Safety Statements: N/A
- WGK Germany:
- RTECS:
- HazardClass: N/A
- PackingGroup: N/A
- Hazardous Substances Data: 1818294-32-4(Hazardous Substances Data)
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1818294-32-4 Usage
Uses
Used in Bioconjugation:SPDP-PEG6-NHS ester is used as a bioconjugation agent for the formation of stable amide bonds between amine-containing molecules. Its SPDP moiety allows for amine and thiol reactive crosslinking, while the NHS ester ensures stable bond formation.
Used in Drug Delivery Systems:
In the pharmaceutical industry, SPDP-PEG6-NHS ester is used as a component in drug delivery systems to improve the solubility and bioavailability of drugs. The hydrophilic PEG linker enhances the compound's solubility in aqueous media, facilitating drug absorption and distribution.
Used in Diagnostics:
SPDP-PEG6-NHS ester is used as a labeling agent in diagnostic applications, such as the conjugation of detection molecules to biomolecules for improved detection sensitivity and specificity.
Used in Anticancer Applications:
In cancer research, SPDP-PEG6-NHS ester can be used as a component in the development of targeted drug delivery systems, taking advantage of its amine and thiol reactive crosslinking properties to attach anticancer agents to specific cellular targets.
Used in Protein Engineering:
In the field of protein engineering, SPDP-PEG6-NHS ester is used as a tool for protein modification and conjugation, allowing for the creation of novel protein constructs with enhanced properties or functions.
Used in Membrane Biochemistry:
Due to its membrane permeability, SPDP-PEG6-NHS ester can be utilized in membrane biochemistry for the study of intracellular crosslinking reactions and the investigation of membrane protein interactions.
Check Digit Verification of cas no
The CAS Registry Mumber 1818294-32-4 includes 10 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 7 digits, 1,8,1,8,2,9 and 4 respectively; the second part has 2 digits, 3 and 2 respectively.Calculate Digit Verification of CAS Registry Number 1818294-32:
(9*1)+(8*8)+(7*1)+(6*8)+(5*2)+(4*9)+(3*4)+(2*3)+(1*2)=194
194 % 10 = 4
So 1818294-32-4 is a valid CAS Registry Number.
1818294-32-4Upstream product
1818294-32-4Downstream Products
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SPDP-PEG6-NHS ester
