1818294-47-1

Basic information

• Product Name: Azido-PEG6-PFP ester
• Synonyms: Azido-PEG6-PFP ester
• CAS NO: 1818294-47-1
• Molecular Formula: C21H28F5N3O8
• Molecular Weight: 545.454336
• Mol File: 1818294-47-1.mol
• Article Data: 0

Chemical Properties

• Appearance: /
• Solubility: Soluble in DCM
• CAS DataBase Reference: Azido-PEG6-PFP ester(CAS DataBase Reference)
• NIST Chemistry Reference: Azido-PEG6-PFP ester(1818294-47-1)
• EPA Substance Registry System: Azido-PEG6-PFP ester(1818294-47-1)

Safety Data

• Hazardous Substances Data: 1818294-47-1(Hazardous Substances Data)

Usage

Description

Azido-PEG6-PFP ester is a high purity polyethylene glycol (PEG) linker that features both azide and PFP ester moieties. This versatile molecule is designed to facilitate chemical reactions and modifications through its distinct functional groups. The azide group is capable of engaging in Click Chemistry reactions with alkynes, such as DBCO and BCN, to form stable triazole groups. Meanwhile, the PFP ester is amine-reactive and exhibits greater resistance to hydrolysis compared to the more commonly used NHS ester, making it a valuable component in various applications.

Uses

Used in Bioconjugation:
Azido-PEG6-PFP ester is used as a bioconjugation agent for the selective and stable attachment of biomolecules, such as proteins, peptides, or other amine-containing compounds. The amine reactivity of the PFP ester allows for the formation of amide bonds, while the azide group enables the use of Click Chemistry for further modifications or the attachment of other molecules.
Used in Drug Delivery Systems:
In the pharmaceutical industry, Azido-PEG6-PFP ester is used as a component in drug delivery systems to improve the solubility, stability, and bioavailability of therapeutic agents. The PEG linker can enhance the pharmacokinetic properties of drugs, while the azide and PFP ester moieties allow for the attachment of drug molecules or other functional groups through various chemical reactions.
Used in Diagnostics and Imaging:
Azido-PEG6-PFP ester is used as a molecular probe in diagnostic and imaging applications. The azide group can be employed in Click Chemistry to attach imaging agents or markers to biomolecules, enabling the detection and visualization of specific targets within biological systems.
Used in Material Science:
In the field of material science, Azido-PEG6-PFP ester is used as a building block for the development of novel materials with tailored properties. The azide and PFP ester moieties facilitate the incorporation of the PEG linker into polymers, dendrimers, or other macromolecular structures, allowing for the fine-tuning of material characteristics such as solubility, mechanical strength, and responsiveness to environmental stimuli.
Used in Chemical Synthesis:
Azido-PEG6-PFP ester is used as an intermediate in the synthesis of complex organic molecules. The azide group can be employed in Click Chemistry reactions to introduce a variety of functional groups, while the PFP ester can be used to generate amide bonds with other molecules, enabling the construction of diverse chemical structures with potential applications in various industries.