181861-89-2

Upstream product

• 181861-29-0 (2S,4R)-4-Benzyloxymethyl-2-tert-butyl-4-isopropyl-5-oxo-oxazolidine-3-carboxylic acid allyl ester 
• 181861-83-6 (R)-4-Benzyloxymethyl-4-isopropyl-oxazolidine-2,5-dione 
• 24424-99-5 di-tert-butyl dicarbonate 
• 181861-86-9 (R)-4-Benzyloxymethyl-4-isopropyl-2,5-dioxo-oxazolidine-3-carboxylic acid tert-butyl ester 

Downstream Products

• 181861-94-9 [(S)-1-((R)-5-Benzyl-5-methyl-4-oxo-4,5-dihydro-1H-pyrrol-2-yl)-1-benzyloxymethyl-2-methyl-propyl]-carbamic acid tert-butyl ester 
• 181861-95-0 [(S)-1-((R)-5-Benzyl-5-methyl-4-oxo-4,5-dihydro-1H-pyrrol-2-yl)-1-hydroxymethyl-2-methyl-propyl]-carbamic acid tert-butyl ester 
• 181861-90-5 ((R)-1-Acetyl-1-benzyloxymethyl-2-methyl-propyl)-carbamic acid tert-butyl ester 

Relevant academic research and scientific papers

The design and synthesis of 2,5-linked pyrrolinones. A potential non- peptide peptidomimetic scaffold

The de novo design and initial synthetic studies directed toward construction of a novel non-peptide scaffold for β-strand/sheet and related secondary peptide structural mimics are described. The scaffold, consisting of a repeating array of 2,5,5-trisubstituted pyrrolinone (enaminone) units punctuated with appropriate amino acid side chains, is conceptually related to our previously successful 3,5-linked polypyrrolinone non-peptide peptidomimetic scaffold. Construction of the 2,5,5-trisubstituted pyrrolinone ring system proceeds via intramolecular condensation of an N-protected amino dione. The latter is prepared from a protected α-amino ketone and aldehyde via an aldol-oxidation reaction sequence.