181869-01-2

Basic information

• Product Name: (2R,4S)-2-benzyl-5-(2,4-dimethoxyphenyl)-4-hydroxy-N-[(2R)-2-hydroxy-2,3-dihydro-1H-inden-1-yl]pentanamide
• CAS NO: 181869-01-2
• Molecular Formula: C₂₉H₃₃NO₅
• Molecular Weight: 475.576
• Mol File: 181869-01-2.mol
• Article Data: 1

Chemical Properties

• Boiling Point: 742.3°C at 760 mmHg
• Flash Point: 402.7°C
• Density: 1.24g/cm³
• Vapor Pressure: 3.86E-23mmHg at 25°C
• Refractive Index: 1.626
• CAS DataBase Reference: (2R,4S)-2-benzyl-5-(2,4-dimethoxyphenyl)-4-hydroxy-N-[(2R)-2-hydroxy-2,3-dihydro-1H-inden-1-yl]pentanamide(CAS DataBase Reference)
• NIST Chemistry Reference: (2R,4S)-2-benzyl-5-(2,4-dimethoxyphenyl)-4-hydroxy-N-[(2R)-2-hydroxy-2,3-dihydro-1H-inden-1-yl]pentanamide(181869-01-2)
• EPA Substance Registry System: (2R,4S)-2-benzyl-5-(2,4-dimethoxyphenyl)-4-hydroxy-N-[(2R)-2-hydroxy-2,3-dihydro-1H-inden-1-yl]pentanamide(181869-01-2)

Safety Data

• Hazardous Substances Data: 181869-01-2(Hazardous Substances Data)

Upstream product

• 151-10-0 1,3-Dimethoxybenzene 
• 158512-24-4 (R)-2-Benzyl-1-((3aS,8aR)-2,2-dimethyl-8,8a-dihydro-3aH-indeno[1,2-d]oxazol-3-yl)-3-(S)-oxiranyl-propan-1-one 

Relevant articles and documents

Aromatic P1 replacements for the highly potent HIV-1 protease inhibitor CRIXIVAN

A series of analogs of CRIXIVAN containing various aromatic P1 ligands were prepared and evaluated for inhibition of the HIV-1 protease enzyme. These new compounds were found to be effective inhibitors at nanomolar concentrations in the in vitro enzyme inhibition assay as well as the whole cell assay.