181930-02-9Relevant academic research and scientific papers
Cycloalkylpyranones and cycloalkyldihydropyrones as HIV protease inhibitors: Exploring the impact of ring size on structure-activity relationships
Romines, Karen R.,Morris, Jeanette K.,Howe, W. Jeffrey,Tomich, Paul K.,Horng, Miao-Miao,Chong, Kong-Teck,Hinshaw, Roger R.,Anderson, David J.,Strohbach, Joseph W.,Turner, Steve-R.,Mizsak, Steve A.
, p. 4125 - 4130 (2007/10/03)
Previously, 3-substituted cycloalkylpyranones, such as 2d, have proven to be effective inhibitors of HIV protease. In an initial series of 3-(1- phenylpropyl) derivatives with various cycloalkyl ring sizes, the cyclooctyl analog was the most potent. We be
