181948-09-4

Basic information

• Product Name: N-4-pentenoyl-(S)-1-phenyl-2-aminoethanol
• Synonyms: N-4-pentenoyl-(S)-1-phenyl-2-aminoethanol
• CAS NO: 181948-09-4
• Molecular Weight: 219.283
• Mol File: 181948-09-4.mol

Chemical Properties

• CAS DataBase Reference: N-4-pentenoyl-(S)-1-phenyl-2-aminoethanol(CAS DataBase Reference)
• NIST Chemistry Reference: N-4-pentenoyl-(S)-1-phenyl-2-aminoethanol(181948-09-4)
• EPA Substance Registry System: N-4-pentenoyl-(S)-1-phenyl-2-aminoethanol(181948-09-4)

Safety Data

• Hazardous Substances Data: 181948-09-4(Hazardous Substances Data)

Upstream product

• 591-80-0 pent-4-enoic acid 
• 56613-81-1 (S)-2-Amino-1-phenyl-1-ethanol 

Downstream Products

• 637767-47-6 (1R,2R,5S,6S,7S)-2-(Allyl-benzyl-carbamoyl)-3-(4-methoxy-benzyl)-4-oxo-10-oxa-3-aza-tricyclo[5.2.1.0^1,5]dec-8-ene-6-carboxylic acid (S)-2-pent-4-enoylamino-1-phenyl-ethyl ester 
• 637767-45-4 (1S,2S,5R,6R,7R)-2-(Allyl-benzyl-carbamoyl)-3-(4-methoxy-benzyl)-4-oxo-10-oxa-3-aza-tricyclo[5.2.1.0^1,5]dec-8-ene-6-carboxylic acid (S)-2-pent-4-enoylamino-1-phenyl-ethyl ester 

Relevant articles and documents

Enzymatic resolution of amines and amino alcohols using pent-4-enoyl derivatives

Racemic amines and amino alcohols were enzymatically resolved by enantioselective acylation using cyanomethyl pent-4-enoate or by enantioselective enzymatic hydrolysis of the dipent-4-enoyl derivatives of amino alcohols to afford chiral pent-4-enamides wh

Stereochemical Control of Skeletal Diversity

(Equation presented) Substrates having appendages that pre-encode skeletal information (σ-elements) can be converted into products having distinct skeletons using a common set of reaction conditions. The sequential use of the Ugi 4CC-IMDA reaction, followed by allylation, hydrolysis, and acylation of a chiral amino alcohol appendage (σ-element), leads to substrates for a ROM/RCM or RCM reaction. The stereochemistry of the a-element and not its constitution controls the outcome of the pathway selected. This work illustrates the potential of linking stereochemical control to the challenging problem of skeletal diversity.