181996-64-5Relevant academic research and scientific papers
The asymmetric total synthesis of (+)-cytotrienin A, an ansamycin-type anticancer drug
Hayashi, Yujiro,Shoji, Mitsuru,Ishikawa, Hayato,Yamaguchi, Junichiro,Tamura, Tomohiro,Imai, Hiroki,Nishigaya, Yosuke,Takabe, Kenichi,Kakeya, Hideaki,Osada, Hiroyuki
supporting information; experimental part, p. 6657 - 6660 (2009/03/12)
(Chemical Equation Presented) A star-studded lineup: (+)-Cytotrienin A was the target of an asymmetric total synthesis featuring an enantioselective aldol reaction, α-aminoxylation, deoxygenation, and a ring-closing metathesis to form the 21-membered macrolactam. This first total synthesis confirms the relative and absolute confguration of the molecule.
