18201-63-3Relevant academic research and scientific papers
Design and synthesis of some new N-phenylanthranilic acids from highly sterically hindered anilines
Li, Zhenghua,Chen, Gang,Qiao, Shu,Liang, Ronghui,Lan, Cong,Xia, Zhining
, p. 1270 - 1279 (2013/04/10)
Some new N-phenylanthranilic acids were designed and synthesized from highly sterically hindered anilines in an efficient and convenient method using CuI as catalyst with microwave irradiation and conventional heating.
Structure-activity relationships in a series of anti-inflammatory N-arylanthranilic acids
Kaltenbronn,Scherrer,Short,Jones,Beatty,Saka,Winder,Wax,Williamson
, p. 621 - 627 (2007/10/02)
A large series of N-arylanthranilic acids has been prepared. Many of these compounds show high anti-inflammatory activity as measured by the anti-UV-erythema test. From this series have come the clinically useful nonsteroidal anti-inflammatory agents, flufenamic acid (Arlef), mefenamic acid (Ponstel), and the latest and most potent agent, N-(2,6-dichloro-m-tolyl)anthranilic acid (meclofenamic acid, Meclomen = the sodium salt). The structure-activity relationships of this series is discussed and a graphical representation is presented which allows the prediction of activity of new agents.
