182013-95-2Relevant academic research and scientific papers
Stereoselective synthesis of β-amino acid derivatives by asymmetric mannich reaction in flow
Yoshida, Masahito,Umeda, Koji,Doi, Takayuki
, p. 1157 - 1163 (2017)
A continuous flow synthesis of β-amino acid derivatives has been demonstrated using an asymmetric Mannich reaction. An enolate of tert-butyl acetate was successfully prepared in 10s at room temperature in a flow reactor, and the desired β-amino acid derivatives were stereoselectively obtained within a short residence time (40 s) in moderate-to-good yields. Sequential Nalkylation of the Mannich product in the flow reactor was also achieved in the presence of DMPU that provided N-alkylated β-amino acid derivatives in good yields.
