18202-73-8

Basic information

• Product Name: TERT-BUTYLCARBAMIDINE HYDROCHLORIDE
• Synonyms: 2,2-DIMETHYLPROPANIMIDAMIDE HYDROCHLORIDE;2,2-DIMETHYLPROPIONAMIDINE HCL;2,2-DIMETHYL-PROPIONAMIDINEHYDROCHLORIDE;TERT-BUTYLCARBAMIDINE HYDROCHLORIDE;T-BUTYLCARBAMIDINE HYDROCHLORIDE;pivalamidine hydrochloride;tert-ButylcarbamidineHCl;trimethylacetamidine hydrochloride
• CAS NO: 18202-73-8
• Molecular Formula: C₅H₁₂N₂*ClH
• Molecular Weight: 136.62
• EINECS: 242-091-1
• Product Categories: pharmacetical;Aliphatics
• Mol File: 18202-73-8.mol
• Article Data: 7

Chemical Properties

• Melting Point: 190 °C
• Boiling Point: 126.9 °C at 760 mmHg
• Flash Point: 30.6 °C
• Appearance: /
• Vapor Pressure: 11.4mmHg at 25°C
• Storage Temp.: Inert atmosphere,Room Temperature
• Sensitive: Hygroscopic
• BRN: 3618865
• CAS DataBase Reference: TERT-BUTYLCARBAMIDINE HYDROCHLORIDE(CAS DataBase Reference)
• NIST Chemistry Reference: TERT-BUTYLCARBAMIDINE HYDROCHLORIDE(18202-73-8)
• EPA Substance Registry System: TERT-BUTYLCARBAMIDINE HYDROCHLORIDE(18202-73-8)

Safety Data

• Hazard Codes: Xi
• Statements: 36/37/38
• Safety Statements: 26-36
• HazardClass: IRRITANT
• Hazardous Substances Data: 18202-73-8(Hazardous Substances Data)

Usage

Uses

Pivalimidamide Hydrochloride is used as a reagent in the preparation of 2-alkyl-4-aryltetrahydropyridopyrimidines and 2-alkyl-4-aryl-tetrahydropyrimidoazepines as selective 5-HT2A antagonists.

InChI:InChI=1/C5H12N2/c1-5(2,3)4(6)7/h1-3H3,(H3,6,7)/p+1

Upstream product

• 58910-26-2 ethyl 2,2-dimethylpropanimidoate hydrochloride 
• 630-18-2 tert-butyl isocyanide 
• 75-36-5 acetyl chloride 

Downstream Products

• 122936-19-0 ethyl (RS)-2-[2-(1,1-dimethylethyl)pyrimidin-5-yl]-3,3-dimethylbutanoate 
• 124052-92-2 2-tert-butyl-5-hydroxy-3,4,5,6-tetrahydropyrimidine hydrochloride 
• 1065267-41-5 6-bromo-2-tert-butyl-7-(2-chlorophenyl)-8,8a-dihydropyrido[2,3-d]pyrimidin-4-amine 
• 450373-69-0 2-t-butyl-5-pyrimidinecarboxylic acid methyl ester 
• 42351-88-2 2-t-butyl-3,4-dihydro-4-oxopyrimidine 

Relevant articles and documents

Guanidine Synthesis: Use of Amidines as Guanylating Agents

The use of amidines for the tandem or one-pot synthesis of guanidines is reported. Guanidines are obtained by oxidative rearrangement of readily available and stable amidines into carbodiimides, followed by in situ reaction with amines. The protocol can be executed under mild reaction conditions (30°C), in a green solvent (dimethyl carbonate). The amine scope is broad, including sterically hindered, oxidation-sensitive and chiral amines. Examples for the synthesis of both acyclic and cyclic guanidines are provided. 2-Propoxyphenyl iodide (2-PrOPhI) by-product, generated from the oxidant [N-(p-toluenesulfonyl)imino](2-propoxyphenyl)iodinane (2-PrOPhINTs), can be isolated in high yields making regeneration of the hypervalent iodine reagent possible. The utility and greenness of the synthetic method versus the state-of-the-art is demonstrated by a new route towards the antihypertensive drug Pinacidil. The process mass intensity (PMI) of the new route is only 24% of the classical one.

Pyrimidine derivatives

This invention provides novel insecticidally and acaricidally active pyrimidine derivatives of formula (I): and stereoisomers thereof, wherein, R1 is selected from alkyl; alkenyl; alkynyl; haloalkyl; haloalkenyl; and cycloalkyl optionally substituted by a

2,6-disubstituted-5-cyano-4-pyrimidinyloxyacetic acid aldose reductase inhibitors

Disclosed herein are 2,6-disubstituted-5-cyano-4-pyrimidinyloxyacetic acids and pharmaceutically acceptable salts thereof and methods of their preparation. The compounds are new aldose reductase inhibitors useful for the treatment or prevention of diabeti