18205-56-6Relevant academic research and scientific papers
Fabrication of ω-Transaminase@Metal-Organic Framework Biocomposites for Efficiently Synthesizing Benzylamines and Pyridylmethylamines
Yu, Jinhai,Zong, Weilu,Ding, Yingying,Liu, Junzhong,Chen, Lina,Zhang, Hongjuan,Jiao, Qingcai
, p. 380 - 390 (2021/11/05)
In this study, ten ω-transaminases (ω-TAs) have been investigated to efficiently catalyze the synthesis of twenty-four functionalized benzylamines and pyridylmethylamines. We optimized the reactions, screened suitable amino donors and compared ω-transaminases activities for all aromatic aldehyde substrates. Under the optimized conditions, eighteen aromatic amines have been obtained with 60.4%–96.6% conversions and isolated only via simple extraction and recrystallization with 18.5%–81% yields on a preparative scale. Furthermore, we first immobilized the Bm-STA onto the MOFs via the physical adsorption to overcome the limitation of free enzyme and improve their industrial applications. The obtained Bm-STA/UiO-66-NH2 composites exhibited not only high enzymes loading (80.4 mg g?1) and enzyme activity recovery (95.8%), but also the better reusability, storage stability, pH stability and the tolerance to acetone and DMF.
A Facile Preparation of 4-(1-acetyl-4(1H)-pyridylidene)-2-oxazolin-5-ones
Hirota, Kazuhiro,Shimamura, Michiya,Ikeda, Mikiko,Ohmori, Shinji
, p. 1551 - 1552 (2007/10/02)
4-(1-Acetyl-4(1H)-pyridylidene)-2-oxazolin-5-ones were prepared by the reaction of acylglycines with pyridine and acetic anhydride under oxygen.Acidic and alkaline hydrolysis of 2-oxazolin-5-ones provided oxazole derivatives, pyridine derivatives and carboxylic acids.
