18209-14-8

Basic information

• Product Name: N-methylmitomycin A
• Synonyms: N-methylmitomycin A;(1aR)-8α-[[(Aminocarbonyl)oxy]methyl]-1,1aβ,2,8,8aβ,8bβ-hexahydro-6,8a-dimethoxy-1,5-dimethylazirino[2',3':3,4]pyrrolo[1,2-a]indole-4,7-dione;Mitomycin F;Mitomycin F, [N-methyl-3H]-
• CAS NO: 18209-14-8
• Molecular Formula: C₁₇H₂₁N₃O₆
• Molecular Weight: 363.36514
• Product Categories: Amines, Chiral Reagents, Heterocycles, Pharmaceuticals, Intermediates & Fine Chemicals
• Mol File: 18209-14-8.mol
• Article Data: 8

Chemical Properties

• Boiling Point: 568°Cat760mmHg
• Flash Point: 297.3°C
• Appearance: /
• Density: 1.46g/cm³
• Vapor Pressure: 6.46E-13mmHg at 25°C
• Refractive Index: 1.633
• Storage Temp.: Refrigerator
• Solubility: DMSO (Slightly), Methanol (Slightly)
• CAS DataBase Reference: N-methylmitomycin A(CAS DataBase Reference)
• NIST Chemistry Reference: N-methylmitomycin A(18209-14-8)
• EPA Substance Registry System: N-methylmitomycin A(18209-14-8)

Safety Data

• Hazardous Substances Data: 18209-14-8(Hazardous Substances Data)

Usage

Uses

6-O-Methyl Mycophenolic Acid Methyl Ester-d9 is used as an intermediate in the formation of mitomycin B (M371895), an antitumor antibiotic that is also used as an antineoplastic.

InChI:InChI=1/C17H21N3O6/c1-7-12(21)11-10(13(22)14(7)24-3)8(6-26-16(18)23)17(25-4)15-9(19(15)2)5-20(11)17/h8-9,15H,5-6H2,1-4H3,(H2,18,23)/t8-,9+,15+,17-,19?/m1/s1

Upstream product

• 4055-39-4 mitomycin A 
• 74-88-4 methyl iodide 
• 801-52-5 porfiromycin 
• 50-07-7 mitomycin C 
• 186581-53-3 diazomethane 
• 10104-18-4 C₁₆H₁₉N₃O₆ 
• 105551-82-4 9-epi-10-O-decarbamoyl-10-O-<(trichloroacetyl)carbamoyl>mitomycin D 
• 78879-24-0 9-epi-10-O-decarbamoyl-10-O-(phenoxycarbonyl)mitomycin D 
• 79026-43-0 9-epi-mitomycin D 
• 78879-23-9 C₁₄H₁₇N₃O₄ 
• 13164-90-4 9-epimitomycin B 
• 77-78-1 dimethyl sulfate 
• 102831-59-4 leucomitomycin 

Downstream Products

• 13164-90-4 9-epimitomycin B 
• 15973-07-6 7-methoxy-1,2-(N-methylaziridino)mitosene 
• 364753-67-3 C₂₂H₃₀N₄O₆ 
• 364753-66-2 C₂₂H₃₀N₄O₆ 
• 801-52-5 porfiromycin 
• 78142-96-8 C₂₂H₂₄N₄O₆ 

Relevant articles and documents

Mass spectrometric studies of antibiotics. I. Mass spectra of mitomycin antibiotics.

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STEROIDAL ANTI-HORMONE HYBRIDS

Disclosed are novel compounds and compositions for inhibition of androgen and estrogen receptor signaling, methods for inhibiting androgen signaling, methods for inhibiting estrogen signaling, methods for inhibiting the interaction between a co-regulatory protein and an androgen or estrogen receptor, and methods for treating cancer.

On the Remarkable Stability of Derivatives of Leucomitomycin F. Novel Mitomycin Analogues

The leuco form of mitomycin F reacts with silica gel in the presence of oxygen to afford 9-epimitomycin B.A notable stability is manifested by hydroquinoid forms (leucomitomycin) bearing a 9,10-exocyclic methylene group.