18212-23-2

Usage

Chemical Properties

White solid

InChI:InChI=1/C8H5ClN2S/c9-7-3-1-6(2-4-7)8-5-12-11-10-8/h1-5H

Upstream product

• 99-91-2 para-chloroacetophenone 
• 1261591-04-1 N'-[(1E)-1-(4-chlorophenyl)ethylidene]-2-(quinolin-8-yloxy)acetohydrazone 
• 1373121-44-8 N′-(2-chloro-1-(4-chlorophenyl)ethylidene)benzohydrazide 
• 937-20-2 p-chlorophenacyl chloride 
• 75230-50-1 p-chloroacetophenone tosylhydrazone 
• 1402671-98-0 C₁₇H₂₄ClN₄O₂S⁽¹⁺⁾*CF₃O₃S^(1-) 
• 1277181-65-3 2-[(Z)-2-[2-[(Z)-2-(aminocarbonyl)hydrazono]-2-(4-chlorophenyl)ethyl]disulfanyl-1-(4-chlorophenyl)ethylidene]-1-hydrazinecarboxamide 
• 130747-32-9 5-azidomethyl-4-(p-chlorophenyl)-1,2,3-thiadiazole 
• 130747-29-4 5-bromomethyl-4-(p-chlorophenyl)-1,2,3-thiadiazole 
• 130747-22-7 4-(4-Chloro-phenyl)-5-methyl-[1,2,3]thiadiazole 
• 120445-85-4 C₉H₁₀ClN₃O 
• 130747-34-1 4-(p-chlorophenyl)-1,2,3-thiadiazole-5-carbaldehyde 
• 22454-52-0 1-benzoyl-2-(4-chloro-α-methylbenzylidene)hydrazine 
• 25445-82-3 ethyl 2-(1-(4-chlorophenyl)ethylidene)hydrazinecarboxylate 

Downstream Products

• 125011-67-8 potassium 2-p-chlorophenylethynethiolate 
• 132606-83-8 2-(4-Chloro-phenylethynylsulfanyl)-1,1-diphenyl-ethanol 
• 132606-84-9 1-(4-Chloro-phenylethynylsulfanyl)-2-phenyl-propan-2-ol 
• 140241-20-9 2-phenylimino-4-p-chlorophenyl-1,3-thiaselenole 
• 54671-34-0 4-(4-Chloro-phenyl)-2-[1-(4-chloro-phenyl)-meth-(Z)-ylidene]-[1,3]dithiole 
• 132606-78-1 1-(4-Chloro-phenylethynylsulfanyl)-propan-2-one 
• 132606-77-0 2-(4-Chloro-phenylethynylsulfanyl)-1-phenyl-ethanone 
• 18212-51-6 1-Ethoxycarbonylthio-2-p-chlorphenyl-ethin 

Relevant academic research and scientific papers

Diiiodine/Potassium Persulfate Mediated Synthesis of 1,2,3-Thiadiazoles from N -Tosylhydrazones and a Thiocyanate Salt as a Sulfur Source under Transition-Metal-Free Conditions

A highly efficient method for the synthesis of 1,2,3-thiadiazoles has been developed by utilizing readily available tosylhydrazones and ammonium thiocyanate with ecofriendly EtOH as the solvent at room temperature. The reaction shows a wide scope of subst

Stereochemistry and mechanistic insights in the [2t + 2i + 2i] annulations of thioketenes and imines

Stereochemical models and mechanistic insights are proposed for [2t + 2i + 2i] annulations of thioketenes and imines on the basis of experimental and computational investigations. In the [2t + 2i + 2

Selective transformations of 2-(p-toluenesulfonyl)-N-tosylhydrazones to substituted 1,2,3-thiadiazoles

Selective transformations of 2-(p-toluenesulfonyl)-N-tosylhydrazones with different sulfur sources have been established. A series of 4-aryl-1,2,3-thiadiazoles and novel 4-aryl-5-tosyl-1,2,3-thiadiazoles were selectively constructed by the adjustment of reaction conditions. These protocols feature short reaction time, good compatibility of functional group, easily available materials, and good selectivity.

Synthesis method of 1, 2, 3-thiadiazole derivative

The invention belongs to the technical field of compound preparation, and discloses a synthesis method of a 1, 2, 3-thiadiazole derivative. The synthesis method of the 1, 2, 3-thiadiazole derivative comprises the following steps: taking an N-tosylhydrazon

I2/CuCl2-promoted one-pot three-component synthesis of aliphatic or aromatic substituted 1,2,3-thiadiazoles

An efficient I2/CuCl2-promoted one-pot three-component strategy for the construction of 1,2,3-thiadiazoles from aliphatic- or aromatic-substituted methyl ketones, p-toluenesulfonyl hydrazide, and potassium thiocyanate has been develo

Preparation method of thiadiazole containing aryl group and alkyl group

The invention discloses a preparation method of thiadiazole containing an aryl group and an alkyl group. Methyl ketone, p-toluenesulfonhydrazide and potassium thiocyanate which are used as a substrateundergo a three-component one-pot reaction in DMSO used

Perylenequinonoid-Catalyzed [4 + 1] and [4 + 2] Annulations of Azoalkenes: Photocatalytic Access to 1,2,3-Thiadiazole/1,4,5,6-Tetrahydropyridazine Derivatives

Nitrogen-containing heterocycles are especially considered "privileged" structural scaffolds for the development of new drugs. However, traditional methods of organic synthesis are mainly based on thermal cycloaddition reaction; thus, the exploration of n

Metal- and Oxidant-free Electrosynthesis of 1,2,3-Thiadiazoles from Element Sulfur and N-tosyl Hydrazones

A metal- and oxidant-free electrochemical method for synthesizing 1,2,3-thiadiazoles by inserting element sulfur into N-tosyl hydrazones is reported. This electrochemical transformation engages electrons as reagents to achieve redox processes, and avoid e

Cascade Trisulfur Radical Anion (S3?-) Addition/Electron Detosylation Process for the Synthesis of 1,2,3-Thiadiazoles and Isothiazoles

Trisulfur radical anion (S3?-) mediated reactions with in situ formed azoalkenes and α,β-usaturated N-sulfonylimines for the construction of 1,2,3-thiadiazoles and isothiazoles has been developed. S3?- is in situ generated from potassium sulfide in DMF. These two approaches provide a new, safe, and simple way to construct 4-subsituted 1,2,3-thiadiazoles, 5-subsituted 1,2,3-thiadiazoles, and isothiazole in good yields. The reactions include the formation of the new C-S and N-S bonds via S3?- addition and electron detosylation under mild conditions.

Coupled Flavin-Iodine Redox Organocatalysts: Aerobic Oxidative Transformation from N-Tosylhydrazones to 1,2,3-Thiadiazoles

A bioinspired two-component redox organocatalyst system using 1,10-bridged flavinium and NH4I was developed to perform environmentally friendly aerobic oxidative ring formation of 1,2,3-thiadiazoles from N-tosylhydrazones and sulfur. The redox