18212-23-2

Usage

Chemical Properties

White solid

InChI:InChI=1/C8H5ClN2S/c9-7-3-1-6(2-4-7)8-5-12-11-10-8/h1-5H

Upstream product

• 22454-52-0 1-benzoyl-2-(4-chloro-α-methylbenzylidene)hydrazine 
• 99-91-2 para-chloroacetophenone 
• 130747-34-1 4-(p-chlorophenyl)-1,2,3-thiadiazole-5-carbaldehyde 
• 1261591-04-1 N'-[(1E)-1-(4-chlorophenyl)ethylidene]-2-(quinolin-8-yloxy)acetohydrazone 
• 1277181-65-3 2-[(Z)-2-[2-[(Z)-2-(aminocarbonyl)hydrazono]-2-(4-chlorophenyl)ethyl]disulfanyl-1-(4-chlorophenyl)ethylidene]-1-hydrazinecarboxamide 
• 1402671-98-0 C₁₇H₂₄ClN₄O₂S⁽¹⁺⁾*CF₃O₃S^(1-) 
• 75230-50-1 p-chloroacetophenone tosylhydrazone 
• 1373121-44-8 N′-(2-chloro-1-(4-chlorophenyl)ethylidene)benzohydrazide 
• 130747-22-7 4-(4-Chloro-phenyl)-5-methyl-[1,2,3]thiadiazole 
• 120445-85-4 C₉H₁₀ClN₃O 
• 25445-82-3 ethyl 2-(1-(4-chlorophenyl)ethylidene)hydrazinecarboxylate 
• 937-20-2 p-chlorophenacyl chloride 
• 130747-32-9 5-azidomethyl-4-(p-chlorophenyl)-1,2,3-thiadiazole 
• 130747-29-4 5-bromomethyl-4-(p-chlorophenyl)-1,2,3-thiadiazole 

Downstream Products

• 125011-67-8 potassium 2-p-chlorophenylethynethiolate 
• 132606-77-0 2-(4-Chloro-phenylethynylsulfanyl)-1-phenyl-ethanone 
• 132606-78-1 1-(4-Chloro-phenylethynylsulfanyl)-propan-2-one 
• 132606-84-9 1-(4-Chloro-phenylethynylsulfanyl)-2-phenyl-propan-2-ol 
• 132606-83-8 2-(4-Chloro-phenylethynylsulfanyl)-1,1-diphenyl-ethanol 
• 140241-20-9 2-phenylimino-4-p-chlorophenyl-1,3-thiaselenole 
• 54671-34-0 4-(4-Chloro-phenyl)-2-[1-(4-chloro-phenyl)-meth-(Z)-ylidene]-[1,3]dithiole 
• 18212-51-6 1-Ethoxycarbonylthio-2-p-chlorphenyl-ethin 

Relevant academic research and scientific papers

Diiiodine/Potassium Persulfate Mediated Synthesis of 1,2,3-Thiadiazoles from N -Tosylhydrazones and a Thiocyanate Salt as a Sulfur Source under Transition-Metal-Free Conditions

A highly efficient method for the synthesis of 1,2,3-thiadiazoles has been developed by utilizing readily available tosylhydrazones and ammonium thiocyanate with ecofriendly EtOH as the solvent at room temperature. The reaction shows a wide scope of subst

Stereochemistry and mechanistic insights in the [2t + 2i + 2i] annulations of thioketenes and imines

Stereochemical models and mechanistic insights are proposed for [2t + 2i + 2i] annulations of thioketenes and imines on the basis of experimental and computational investigations. In the [2t + 2i + 2

Synthesis method of 1, 2, 3-thiadiazole derivative

The invention belongs to the technical field of compound preparation, and discloses a synthesis method of a 1, 2, 3-thiadiazole derivative. The synthesis method of the 1, 2, 3-thiadiazole derivative comprises the following steps: taking an N-tosylhydrazon

Selective transformations of 2-(p-toluenesulfonyl)-N-tosylhydrazones to substituted 1,2,3-thiadiazoles

Selective transformations of 2-(p-toluenesulfonyl)-N-tosylhydrazones with different sulfur sources have been established. A series of 4-aryl-1,2,3-thiadiazoles and novel 4-aryl-5-tosyl-1,2,3-thiadiazoles were selectively constructed by the adjustment of reaction conditions. These protocols feature short reaction time, good compatibility of functional group, easily available materials, and good selectivity.

Metal- and Oxidant-free Electrosynthesis of 1,2,3-Thiadiazoles from Element Sulfur and N-tosyl Hydrazones

A metal- and oxidant-free electrochemical method for synthesizing 1,2,3-thiadiazoles by inserting element sulfur into N-tosyl hydrazones is reported. This electrochemical transformation engages electrons as reagents to achieve redox processes, and avoid e

I2/CuCl2-promoted one-pot three-component synthesis of aliphatic or aromatic substituted 1,2,3-thiadiazoles

An efficient I2/CuCl2-promoted one-pot three-component strategy for the construction of 1,2,3-thiadiazoles from aliphatic- or aromatic-substituted methyl ketones, p-toluenesulfonyl hydrazide, and potassium thiocyanate has been develo

Preparation method of thiadiazole containing aryl group and alkyl group

The invention discloses a preparation method of thiadiazole containing an aryl group and an alkyl group. Methyl ketone, p-toluenesulfonhydrazide and potassium thiocyanate which are used as a substrateundergo a three-component one-pot reaction in DMSO used

Perylenequinonoid-Catalyzed [4 + 1] and [4 + 2] Annulations of Azoalkenes: Photocatalytic Access to 1,2,3-Thiadiazole/1,4,5,6-Tetrahydropyridazine Derivatives

Nitrogen-containing heterocycles are especially considered "privileged" structural scaffolds for the development of new drugs. However, traditional methods of organic synthesis are mainly based on thermal cycloaddition reaction; thus, the exploration of n

Cascade Trisulfur Radical Anion (S3?-) Addition/Electron Detosylation Process for the Synthesis of 1,2,3-Thiadiazoles and Isothiazoles

Trisulfur radical anion (S3?-) mediated reactions with in situ formed azoalkenes and α,β-usaturated N-sulfonylimines for the construction of 1,2,3-thiadiazoles and isothiazoles has been developed. S3?- is in situ generated from potassium sulfide in DMF. These two approaches provide a new, safe, and simple way to construct 4-subsituted 1,2,3-thiadiazoles, 5-subsituted 1,2,3-thiadiazoles, and isothiazole in good yields. The reactions include the formation of the new C-S and N-S bonds via S3?- addition and electron detosylation under mild conditions.

Coupled Flavin-Iodine Redox Organocatalysts: Aerobic Oxidative Transformation from N-Tosylhydrazones to 1,2,3-Thiadiazoles

A bioinspired two-component redox organocatalyst system using 1,10-bridged flavinium and NH4I was developed to perform environmentally friendly aerobic oxidative ring formation of 1,2,3-thiadiazoles from N-tosylhydrazones and sulfur. The redox