18212-25-4

Upstream product

• 88-15-3 2-Acetylthiophene 
• 1261591-10-9 2-(quinolin-8-yloxy)-N'-[(1E)-1-(thiophen-2-yl)ethylidene]acetohydrazone 
• 1402672-10-9 C₁₅H₂₃N₄O₂S₂⁽¹⁺⁾*CF₃O₃S^(1-) 
• 25445-78-7 methyl 2-thienyl ketone N-ethoxycarbonylhydrazone 

Downstream Products

• 1001197-37-0 [Au(2-C₄H₃S-CC-S)(AsPh₃)] 
• 1001197-28-9 [Au₂(2-C₅H₃S-CCS)2(1,2-bis(diphenylphosphino)ethane)] 
• 1001197-38-1 [Au(2-C₄H₃S-CC-S)(PPh₂Me)] 
• 1001197-32-5 PPN[Au(2-C₆H₃CCS)2] 
• 1001197-21-2 [Au(2-C₄H₃S-CC-S)(PPh₃)] 
• 1001197-39-2 [Au(2-C₄H₃S-CC-S)(PPhMe₂)] 

Relevant academic research and scientific papers

Diiiodine/Potassium Persulfate Mediated Synthesis of 1,2,3-Thiadiazoles from N -Tosylhydrazones and a Thiocyanate Salt as a Sulfur Source under Transition-Metal-Free Conditions

A highly efficient method for the synthesis of 1,2,3-thiadiazoles has been developed by utilizing readily available tosylhydrazones and ammonium thiocyanate with ecofriendly EtOH as the solvent at room temperature. The reaction shows a wide scope of subst

Synthesis method of 1, 2, 3-thiadiazole derivative

The invention belongs to the technical field of compound preparation, and discloses a synthesis method of a 1, 2, 3-thiadiazole derivative. The synthesis method of the 1, 2, 3-thiadiazole derivative comprises the following steps: taking an N-tosylhydrazon

Metal- and Oxidant-free Electrosynthesis of 1,2,3-Thiadiazoles from Element Sulfur and N-tosyl Hydrazones

A metal- and oxidant-free electrochemical method for synthesizing 1,2,3-thiadiazoles by inserting element sulfur into N-tosyl hydrazones is reported. This electrochemical transformation engages electrons as reagents to achieve redox processes, and avoid e

Coupled Flavin-Iodine Redox Organocatalysts: Aerobic Oxidative Transformation from N-Tosylhydrazones to 1,2,3-Thiadiazoles

A bioinspired two-component redox organocatalyst system using 1,10-bridged flavinium and NH4I was developed to perform environmentally friendly aerobic oxidative ring formation of 1,2,3-thiadiazoles from N-tosylhydrazones and sulfur. The redox

TBAI-Catalyzed Reaction between N-Tosylhydrazones and Sulfur: A Procedure toward 1,2,3-Thiadiazole

A TBAI-catalyzed reaction between N-tosyl hydrazone and sulfur was developed, leading to 1,2,3-thiadiazoles in moderate to good yields. It represents a facile and practical procedure to access thiadiazole under metal-free conditions. This procedure serves

Ionic liquid as soluble support for synthesis of 1,2,3-thiadiazoles and 1,2,3-selenadiazoles

A convenient synthesis of 1,2,3-thiadiazoles and 1,2,3-selenadiazoles was achieved using an ionic liquid as a novel soluble support. Ionic liquid-supported sulfonyl hydrazine was synthesized and reacted with a number of ketones to afford the corresponding ionic liquid-supported hydrazones that were converted to 1,2,3-thiadiazoles in the presence of thionyl chloride. The reaction of ionic liquid-supported hydrazones with selenium dioxide in acetonitrile afforded 1,2,3-selenadiazoles. The advantages of this methodology were the ease of workup, simple reaction conditions, and high purity.

Synthesis, characterization, antiamoebic activity and cytotoxicity of novel 2-(quinolin-8-yloxy) acetohydrazones and their cyclized products (1,2,3-thiadiazole and 1,2,3-selenadiazole derivatives)

A series of 1,2,3-thiadiazole and 1,2,3-selenadiazole derivatives were synthesized by the cyclization of novel 2-(quinolin-8-yloxy) acetohydrazones. In vitro antiamoebic activity was performed against HM1: IMSS strain of Entamoeba histolytica. The results showed that all the 2-(quinolin-8-yloxy) acetohydrazones were more active than their cyclized products (1,2,3-thiadiazole and 1,2,3-selenadiazole derivatives). SAR showed that the compounds having quinoline ring and hydrazone linkage with free N-H group are responsible for higher antiamoebic activity. The cytotoxic studies of these compounds on human breast cancer MCF-7 cell line showed that all the compounds were nontoxic at the concentration range of 1.56-50 μM.

Synthesis and properties of alkynethiolate gold(i) complexes

A series of alkynethiolate gold(i) derivatives have been synthesised by the cleavage of 4-monosubstituted 1,2,3-thiadiazoles in the presence of strong bases. The syntheses of the 1,2,3-thiadiazoles with p-cyanophenyl, p-tolyl, 2-thienyl, 3-thienyl and 9,9-dimethylfluoren-2-yl fragments are also described. All the complexes have been characterised by spectroscopic techniques and the complexes [Au(p-CH3-C6H4-CC-S)PPh3], [Au(3-C4H3S-CC-S)PPh3] and PPN[Au(p-CH 3-C6H4-CC-S)(C6F5)] by X-ray analysis. The electrochemically polymerizable mononuclear bis(alkynethiolate) gold(i) complex PPN[Au(3-C4H3S-CC-S) 2] is also described, including its electropolymerization and electrochemical properties. This journal is The Royal Society of Chemistry.

The 1,2,3-thiadiazole route to new vinylogue tetrathiafulvalenes

Cleavage of 1,4-dithiafulvene-substituted 1,2,3-thiadiazoles with base and dimerisation of the resulting alkyne-1-thiolate gives new tetrathiafulvalene-type vinylogue extended π-donors in a one pot reaction. The solvent-/base-system used (acetonitrile/NaH) was optimised for the synthesis of 1,3-dithiole-2-thiones via this route. Efficient synthesis of the important 4-formyl-1,3-dithiol-2-thione and its coupling to 2,6(7)-bisformyltetrathiafulvalene is presented. Preparation of a number of new 1,4-dithiafulvenes are reported.