18212-83-4Relevant academic research and scientific papers
Palladium-catalyzed denitrative α-arylation of ketones with nitroarenes
Li, Zhirong,Peng, Yonggang,Wu, Tao
supporting information, (2021/02/16)
The palladium-catalyzed α-arylation of ketones with readily available nitroarenes and nitroheteroarenes provides access to useful α-aryl and α-heteroaryl ketones. The use of the Pd/ BrettPhos catalysts was critical to achieve high efficiency for these transformations, whereas other catalysts led to decreased yields or no conversions. The intramolecular type substrate was also applied in this methodology and gave a chromone derivative. Polyaromatic carbonyl compounds can be easily obtained by multicomponent tandem reactions, via nucleophilic aromatic substitution (SNAr) or cross-coupling reaction followed by this denitrative arylation. Kinetic experiments show that the electronic effect of nitrobenzenes has a greater effect on the reaction rate than the electronic effect of ketones.
Palladium-catalyzed carbonylative negishi-type coupling of aryl iodides with benzyl chlorides
Wu, Xiao-Feng,Schranck, Johannes,Neumann, Helfried,Beller, Matthias
supporting information; experimental part, p. 40 - 44 (2012/03/11)
Do the competition: The synthesis of 1,2-diarylethanones has been accomplished using the palladium-catalyzed coupling of aryl iodides and CO/benzyl chlorides or benzoyl chlorides. These reactions proceed smoothly in the presence of zinc powder to afford the products in moderate to excellent yields.
Arylation of α-pivaloxyl ketones with arylboronic reagents via Ni-catalyzed sp3 C-O activation
Huang, Kun,Li, Gang,Huang, Wei-Ping,Yu, Da-Gang,Shi, Zhang-Jie
, p. 7224 - 7226 (2011/08/09)
A Suzuki-Miyaura coupling of α-pivaloxyl ketones via Ni-catalyzed sp3 C-O activation to produce α-aryl ketones is developed. This study offers a convenient method to construct α-arylation products from readily available α-hydroxyl carbonyl compounds.
