182133-36-4

Basic information

• Product Name: [6-methoxy-2-(4-methanesulfonyloxy-phenyl)]benzo[b]thiophene
• Synonyms: [6-methoxy-2-(4-methanesulfonyloxy-phenyl)]benzo[b]thiophene
• CAS NO: 182133-36-4
• Molecular Weight: 334.417
• Mol File: 182133-36-4.mol
• Article Data: 7

Chemical Properties

• CAS DataBase Reference: [6-methoxy-2-(4-methanesulfonyloxy-phenyl)]benzo[b]thiophene(CAS DataBase Reference)
• NIST Chemistry Reference: [6-methoxy-2-(4-methanesulfonyloxy-phenyl)]benzo[b]thiophene(182133-36-4)
• EPA Substance Registry System: [6-methoxy-2-(4-methanesulfonyloxy-phenyl)]benzo[b]thiophene(182133-36-4)

Safety Data

• Hazardous Substances Data: 182133-36-4(Hazardous Substances Data)

Upstream product

• 68574-35-6 4-bromophenyl methanesulfonate 
• 182133-35-3 6-methoxy-benzo[b]thiophen-2-yl boronic acid 

Downstream Products

• 182133-38-6 [6-Hydroxy-2-(4-methanesulfonyloxyphenyl)]benzo[b]thiophene 

Relevant articles and documents

Treatment of central nervous system disorders with selective estrogen receptor modulators

The present invention provides a method of treating depression, mood swings, or Alzheimer's disease in a patient in need of such treatment by administering a selective estrogen receptor modulating compound of the formula in which R1 and R2 are independently hydroxy and alkoxy of one to four carbon atoms; and R3 and R4 are independently methyl or ethyl, or R3 and R4, taken together with the nitrogen atom to which they are attached, form a pyrrolidino, methyl-pyrrolidino, dimethylpyrrolidino, piperidino, morpholino, or hexamethyleneimino ring.

Method of treating estrogen dependent cancers

A method for alleviating the symptoms of post-menopausal syndrome comprising administering to a woman in need thereof an effective amount of a compound of formula I STR1 wherein R1a is --H or --OR7a in which R7a is --H or a hydroxy protecting group; R2a is --H, halo, or --OR8a in which R8a is --H or a hydroxy protecting group; R3 is 1-piperidinyl, 1-pyrrolidino, methyl-1-pyrrolidinyl, dimethyl-1-pyrrolidino, 4-morpholino, dimethylamino, diethylamino, diisopropylamino, or 1-hexamethyleneimino; n is 2 or 3; and Z is --O-- or --S--; or a pharmaceutically acceptable salt thereof.

Benzothiophene compounds, intermediates, compositions, and methods

A method for alleviating the symptoms of post-menopausal syndrome comprising administering to a woman in need thereof an effective amount of a compound of formula I wherein R1a is --H or --OR7a in which R7a is --H or a hydroxy protecting group; R2a is --H, halo, or --OR8a in which R8a is --H or a hydroxy protecting group; R3 is 1-piperidinyl, 1-pyrrolidino, methyl-1-pyrrolidinyl, dimethyl-1-pyrrolidino, 4-morpholino, dimethylamino, diethylamino, diisopropylamino, or 1-hexamethyleneimino; n is 2 or 3; and Z is --O-- or --S--; or a pharmaceutically acceptable salt thereof, and further comprising administering to said woman an effective amount of progestin.