182144-31-6Relevant articles and documents
Benzylidene ketal derivatives as M2 muscarinic receptor antagonists
Boyle, Craig D,Chackalamannil, Samuel,Chen, Lian-Yong,Dugar, Sundeep,Pushpavanam, Pradeep,Billard, William,Binch III, Herbert,Crosby, Gordon,Cohen-Williams, Mary,Coffin, Vicki L,Duffy, Ruth A,Ruperto, Vilma,Lachowicz, Jean E
, p. 2727 - 2730 (2007/10/03)
Benzylidene ketal derivatives were investigated as selective M2 receptor antagonists for the treatment of Alzheimer's disease. Compound 10 was discovered to have subnanomolar M2 receptor affinity and 100-fold selectivity against other muscarinic receptors. Also, 10 demonstrated in vivo efficacy in rodent models of muscarinic activity and cognition. (C) 2000 Elsevier Science Ltd.